Genetics and immunity of Anopheles response to the entomopathogenic fungus Metarhizium anisopliae overlap with immunity to Plasmodium.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
15 04 2022
15 04 2022
Historique:
received:
07
02
2022
accepted:
28
03
2022
pubmed:
17
4
2022
medline:
20
4
2022
entrez:
16
4
2022
Statut:
epublish
Résumé
Entomopathogenic fungi have been explored as a potential biopesticide to counteract the insecticide resistance issue in mosquitoes. However, little is known about the possibility that genetic resistance to fungal biopesticides could evolve in mosquito populations. Here, we detected an important genetic component underlying Anopheles coluzzii survival after exposure to the entomopathogenic fungus Metarhizium anisopliae. A familiality study detected variation for survival among wild mosquito isofemale pedigrees, and genetic mapping identified two loci that significantly influence mosquito survival after fungus exposure. One locus overlaps with a previously reported locus for Anopheles susceptibility to the human malaria parasite Plasmodium falciparum. Candidate gene studies revealed that two LRR proteins encoded by APL1C and LRIM1 genes in this newly mapped locus are required for protection of female A. coluzzii from M. anisopliae, as is the complement-like factor Tep1. These results indicate that natural Anopheles populations already segregate frequent genetic variation for differential mosquito survival after fungal challenge and suggest a similarity in Anopheles protective responses against fungus and Plasmodium. However, this immune similarity raises the possibility that fungus-resistant mosquitoes could also display enhanced resistance to Plasmodium, suggesting an advantage of selecting for fungus resistance in vector populations to promote naturally diminished malaria vector competence.
Identifiants
pubmed: 35428783
doi: 10.1038/s41598-022-10190-3
pii: 10.1038/s41598-022-10190-3
pmc: PMC9012835
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6315Subventions
Organisme : NIAID NIH HHS
ID : R01 AI145999
Pays : United States
Organisme : NIAID NIH HHS
ID : AI145999
Pays : United States
Informations de copyright
© 2022. The Author(s).
Références
PLoS Pathog. 2015 Dec 03;11(12):e1005306
pubmed: 26633695
Cell. 2001 Mar 9;104(5):709-18
pubmed: 11257225
BMC Genomics. 2015 Oct 13;16:779
pubmed: 26462916
Science. 2006 Apr 28;312(5773):577-9
pubmed: 16645095
Science. 2002 Oct 4;298(5591):213-6
pubmed: 12364806
Science. 2005 Jun 10;308(5728):1638-41
pubmed: 15947189
PLoS Pathog. 2012;8(5):e1002742
pubmed: 22693451
Malar J. 2012 Nov 22;11:383
pubmed: 23171286
Parasit Vectors. 2020 Jan 30;13(1):43
pubmed: 32000840
Lett Appl Microbiol. 2013 Sep;57(3):193-9
pubmed: 23638865
Future Microbiol. 2010 Mar;5(3):339-41
pubmed: 20210542
Elife. 2017 Jun 23;6:
pubmed: 28643631
Malar J. 2015 Jan 28;14:22
pubmed: 25626485
J Vis Exp. 2017 Jul 30;(125):
pubmed: 28784940
Front Microbiol. 2016 Jan 05;6:1500
pubmed: 26779155
Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16817-22
pubmed: 20826443
Curr Opin Microbiol. 2012 Jun;15(3):285-91
pubmed: 22538050
Parasit Vectors. 2020 May 16;13(1):259
pubmed: 32416733
Cell. 2004 Mar 5;116(5):661-70
pubmed: 15006349
Front Microbiol. 2020 Feb 26;11:306
pubmed: 32174902
PLoS Negl Trop Dis. 2018 Apr 23;12(4):e0006433
pubmed: 29684026
Malar J. 2010 Jan 19;9:22
pubmed: 20085659
Malar J. 2018 Dec 5;17(1):454
pubmed: 30518395
Science. 2005 Jun 10;308(5728):1641-2
pubmed: 15947190
PLoS Negl Trop Dis. 2021 Nov 29;15(11):e0009984
pubmed: 34843477
PLoS Pathog. 2010 Sep 16;6(9):e1001112
pubmed: 20862317
Parasit Vectors. 2011 Feb 22;4:23
pubmed: 21342492
Nat Rev Microbiol. 2007 May;5(5):377-83
pubmed: 17426726
Malar J. 2007 Jul 06;6:87
pubmed: 17612409
Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):5994-5999
pubmed: 28533370
Parasit Vectors. 2014 Apr 10;7:176
pubmed: 24721548
PLoS One. 2010 Aug 11;5(8):e12081
pubmed: 20711409
Trends Parasitol. 2011 Feb;27(2):91-8
pubmed: 20843745
J Exp Biol. 2014 Nov 1;217(Pt 21):3823-33
pubmed: 25267846
Malar J. 2010 Jan 20;9:27
pubmed: 20089180
Malar J. 2010 Aug 27;9:246
pubmed: 20799967
PLoS Pathog. 2012;8(11):e1003029
pubmed: 23166497
Malar J. 2012 Jul 06;11:226
pubmed: 22770378
PLoS Pathog. 2009 Sep;5(9):e1000576
pubmed: 19750215
Cell Host Microbe. 2009 Mar 19;5(3):273-84
pubmed: 19286136
PLoS One. 2008;3(11):e3672
pubmed: 18989366
Science. 2009 Apr 10;324(5924):258-61
pubmed: 19264986
Science. 2004 Mar 26;303(5666):2030-2
pubmed: 15044804