Rhesus negative males have an enhanced IFNγ-mediated immune response to influenza A virus.
Journal
Genes and immunity
ISSN: 1476-5470
Titre abrégé: Genes Immun
Pays: England
ID NLM: 100953417
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
received:
03
12
2021
accepted:
17
03
2022
revised:
14
03
2022
pubmed:
17
4
2022
medline:
29
4
2022
entrez:
16
4
2022
Statut:
ppublish
Résumé
The Rhesus D antigen (RhD) has been associated with susceptibility to several viral infections. Reports suggest that RhD-negative individuals are better protected against infectious diseases and have overall better health. However, potential mechanisms contributing to these associations have not yet been defined. Here, we used transcriptomic and genomic data from the Milieu Interieur cohort of 1000 healthy individuals to explore the effect of Rhesus status on the immune response. We used the rs590787 SNP in the RHD gene to classify the 1000 donors as either RhD-positive or -negative. Whole blood was stimulated with LPS, polyIC, and the live influenza A virus and the NanoString human immunology panel of 560 genes used to assess donor immune response and to investigate sex-specific effects. Using regression analysis, we observed no significant differences in responses to polyIC or LPS between RhD-positive and -negative individuals. However, upon sex-specific analysis, we observed over 40 differentially expressed genes (DEGs) between RhD-positive (n = 384) and RhD-negative males (n = 75) after influenza virus stimulation. Interestingly these Rhesus-associated differences were not seen in females. Further investigation, using gene set enrichment analysis, revealed enhanced IFNγ signalling in RhD-negative males. This amplified IFNγ signalling axis may explain the increased viral resistance previously described in RhD-negative individuals.
Identifiants
pubmed: 35428875
doi: 10.1038/s41435-022-00169-5
pii: 10.1038/s41435-022-00169-5
pmc: PMC9012157
doi:
Substances chimiques
Lipopolysaccharides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
93-98Investigateurs
Laurent Abel
(L)
Andres Alcover
(A)
Hugues Aschard
(H)
Philippe Bousso
(P)
Nollaig Bourke
(N)
Petter Brodin
(P)
Pierre Bruhns
(P)
Nadine Cerf-Bensussan
(N)
Ana Cumano
(A)
Christophe D'Enfert
(C)
Ludovic Deriano
(L)
Marie-Agnès Dillies
(MA)
James Di Santo
(JD)
Françoise Dromer
(F)
Gérard Eberl
(G)
Jost Enninga
(J)
Jacques Fellay
(J)
Ivo Gomperts-Boneca
(I)
Milena Hasan
(M)
Gunilla Karlsson Hedestam
(GK)
Serge Hercberg
(S)
Molly A Ingersoll
(MA)
Olivier Lantz
(O)
Rose Anne Kenny
(RA)
Mickaël Ménager
(M)
Hugo Mouquet
(H)
Cliona O'Farrelly
(C)
Etienne Patin
(E)
Sandra Pellegrini
(S)
Antonio Rausell
(A)
Frédéric Rieux-Laucat
(F)
Lars Rogge
(L)
Magnus Fontes
(M)
Anavaj Sakuntabhai
(A)
Olivier Schwartz
(O)
Benno Schwikowski
(B)
Spencer Shorte
(S)
Frédéric Tangy
(F)
Antoine Toubert
(A)
Mathilde Touvier
(M)
Marie-Noëlle Ungeheuer
(MN)
Christophe Zimmer
(C)
Matthew L Albert
(ML)
Darragh Duffy
(D)
Lluis Quintana-Murci
(L)
Informations de copyright
© 2022. The Author(s).
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