Blood-based biomarker in Parkinson's disease: potential for future applications in clinical research and practice.
Alpha-synuclein
Biomarker
Parkinsonian syndromes
Parkinson’s disease
Journal
Journal of neural transmission (Vienna, Austria : 1996)
ISSN: 1435-1463
Titre abrégé: J Neural Transm (Vienna)
Pays: Austria
ID NLM: 9702341
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
received:
09
03
2022
accepted:
27
03
2022
pubmed:
17
4
2022
medline:
14
9
2022
entrez:
16
4
2022
Statut:
ppublish
Résumé
The clinical presentation of Parkinson's disease (PD) is both complex and heterogeneous, and its precise classification often requires an intensive work-up. The differential diagnosis, assessment of disease progression, evaluation of therapeutic responses, or identification of PD subtypes frequently remains uncertain from a clinical point of view. Various tissue- and fluid-based biomarkers are currently being investigated to improve the description of PD. From a clinician's perspective, signatures from blood that are relatively easy to obtain would have great potential for use in clinical practice if they fulfill the necessary requirements as PD biomarker. In this review article, we summarize the knowledge on blood-based PD biomarkers and present both a researcher's and a clinician's perspective on recent developments and potential future applications.
Identifiants
pubmed: 35428925
doi: 10.1007/s00702-022-02498-1
pii: 10.1007/s00702-022-02498-1
pmc: PMC9463345
doi:
Substances chimiques
Biomarkers
0
alpha-Synuclein
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1201-1217Informations de copyright
© 2022. The Author(s).
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