Sex differences in circulating proteins of patients with rheumatoid arthritis: A cohort study.
pathophysiology
proteomic biomarkers
rheumatoid arthritis
sex differences
Journal
International journal of rheumatic diseases
ISSN: 1756-185X
Titre abrégé: Int J Rheum Dis
Pays: England
ID NLM: 101474930
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
pubmed:
17
4
2022
medline:
25
6
2022
entrez:
16
4
2022
Statut:
ppublish
Résumé
Differences in proteomic profiles between men and women may provide insights into the biological pathways that contribute to known sex differences in rheumatoid arthritis (RA). Studies focusing on sex differences in circulating proteins in RA patients are scarce. Our objective was to investigate the sex differences in circulating proteins of RA patients. Cohort study enrolling 399 RA patients. Ninety-four circulating protein-biomarkers (92CVDIIOlink In all, 306 (76.7%) patients were women. Compared with men, women had less visceral fat, smoked less, had diabetes and chronic obstructive pulmonary disease less frequently, and expressed more fatigue, anxiety, and depression. The association with cardiovascular outcomes did not differ between sexes. After adjusting for potential confounders, women expressed higher levels of circulating proteins related to adipokine signaling and vascular function (eg, leptin and vascular endothelial growth factor), whereas men expressed higher levels of circulating proteins related to extracellular matrix organization and inflammation (eg, matrix metalloproteinase-2 and C-reactive protein). These results were not found in patients without RA. Sex differences in circulating proteins reflect distinct pathways implicated in the pathogenesis of RA, including inflammation, adiposity, angiogenesis, and extracellular matrix organization. These findings may help further investigations into factors underlying sex-based differences and allow future studies focused on sex-specific personalized treatment approaches in RA. gov ID: NCT03960515.
Identifiants
pubmed: 35429115
doi: 10.1111/1756-185X.14323
doi:
Substances chimiques
Biomarkers
0
Vascular Endothelial Growth Factor A
0
C-Reactive Protein
9007-41-4
Matrix Metalloproteinase 2
EC 3.4.24.24
Banques de données
ClinicalTrials.gov
['NCT03960515']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
669-677Subventions
Organisme : RHU Fight-HF
Organisme : Investissements d'Avenir
ID : ANR-15-RHUS-0004
Organisme : French PIA project Lorraine Université d'Excellence
ID : ANR-15-IDEX-04-LUE
Organisme : Contrat de Plan Etat Lorraine IT2MP and FEDER Lorraine
Informations de copyright
© 2022 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.
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