Iatrogenic doramectin overdosing causes toxicity in sheep: A case report.
Iatrogenic
Macrocyclic lactones
Ruminant
Toxicity
Journal
Veterinary parasitology, regional studies and reports
ISSN: 2405-9390
Titre abrégé: Vet Parasitol Reg Stud Reports
Pays: Netherlands
ID NLM: 101680410
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
received:
18
10
2021
revised:
26
01
2022
accepted:
21
03
2022
entrez:
18
4
2022
pubmed:
19
4
2022
medline:
20
4
2022
Statut:
ppublish
Résumé
Macrocyclic lactones are widely used endectocides in ruminants, with a high margin of safety for labeled indications. No previous report of iatrogenic doramectin overdosing has been published. We report an outbreak in a sheep flock in Northeast Patagonia, Argentina. Toxicity signs were observed in more than 10% and 59% of ewes and lambs, respectively, particularly those with low body condition, treated with doramectin 3.5% long-acting injectable formulation, presumably at the indicated dose of 700 μg/kg. Clinical signs included lethargy, mydriasis and coma. Doramectin concentration in blood samples was 826.8 (±119.3) ng/ml. Cerebrospinal fluid (CSF) and liver doramectin concentration in euthanized lambs were 3.26-4.28 ng/ml and 8506-8772 ng/g, respectively. Epidemiological and clinical information, and high doramectin concentration were sufficient to confirm the neurotoxicity. Scarce fat deposition could have altered doramectin pharmacokinetic which may have accounted for the observed neurotoxicity. Special care should be taken when animals under similar nutritional conditions are treated with macrocyclic lactones.
Identifiants
pubmed: 35431078
pii: S2405-9390(22)00038-7
doi: 10.1016/j.vprsr.2022.100722
pii:
doi:
Substances chimiques
Anthelmintics
0
Ivermectin
70288-86-7
doramectin
KGD7A54H5P
Types de publication
Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
100722Informations de copyright
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