Reduction in Volume of Nucleus Basalis of Meynert Is Specific to Parkinson's Disease and Progressive Supranuclear Palsy but Not to Multiple System Atrophy.
Parkinson’s disease
cholinergic innervation
multiple system atrophy
nucleus basalis of Meynert
progressive supranuclear palsy
subcortical dementia
voxel-based morphometry
Journal
Frontiers in aging neuroscience
ISSN: 1663-4365
Titre abrégé: Front Aging Neurosci
Pays: Switzerland
ID NLM: 101525824
Informations de publication
Date de publication:
2022
2022
Historique:
received:
10
01
2022
accepted:
24
02
2022
entrez:
18
4
2022
pubmed:
19
4
2022
medline:
19
4
2022
Statut:
epublish
Résumé
To study T1-weighted magnetic resonance images from patients with progressive supranuclear palsy (PSP, Significantly lower nbM volumes in patients with PSP and PD compared to HC or patients with MSA were found. No significant correlations between MMSE and nbM volumes were detected in any of the subgroups. No significant correlations were found between clinical scores and nbM volumes in PSP or other groups. nbM volumes were reduced both in PD and PSP but not in MSA. The lack of significant correlations between nbM and cognitive measures suggests that other factors, such as frontal atrophy, may play a more important role than subcortical cholinergic atrophy in PSP patients. These results may indicate that other drug-targets are needed to improve cognitive function in PSP patients.
Identifiants
pubmed: 35431891
doi: 10.3389/fnagi.2022.851788
pmc: PMC9012106
doi:
Types de publication
Journal Article
Langues
eng
Pagination
851788Informations de copyright
Copyright © 2022 Rogozinski, Klietz, Respondek, Oertel, Grothe, Pereira and Höglinger.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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