Biochemical and proteomic analyses of venom from a new pit viper,

Antivenom Cross-neutralization Pit viper Protobothrops Snakebite Venom proteomics Viperidae

Journal

The journal of venomous animals and toxins including tropical diseases
ISSN: 1678-9199
Titre abrégé: J Venom Anim Toxins Incl Trop Dis
Pays: Brazil
ID NLM: 101201501

Informations de publication

Date de publication:
2022
Historique:
received: 16 07 2021
accepted: 15 12 2021
entrez: 18 4 2022
pubmed: 19 4 2022
medline: 19 4 2022
Statut: epublish

Résumé

A new pit viper, PKV was evaluated for its neutralizing capacity (ER Intravenous LD Enzymatic activities of PKV are similarly related to other viperid venoms in this study by quantitatively hematotoxic properties. Three major venom toxins were responsible for coagulopathy in PKV envenomation. The antivenom HPAV was considered effective in neutralizing the lethality, procoagulant and hemorrhagic effects of PKV.

Sections du résumé

Background UNASSIGNED
A new pit viper,
Methods UNASSIGNED
PKV was evaluated for its neutralizing capacity (ER
Results UNASSIGNED
Intravenous LD
Conclusions UNASSIGNED
Enzymatic activities of PKV are similarly related to other viperid venoms in this study by quantitatively hematotoxic properties. Three major venom toxins were responsible for coagulopathy in PKV envenomation. The antivenom HPAV was considered effective in neutralizing the lethality, procoagulant and hemorrhagic effects of PKV.

Identifiants

pubmed: 35432492
doi: 10.1590/1678-9199-JVATITD-2021-0080
pmc: PMC9005077
doi:

Types de publication

Journal Article

Langues

eng

Pagination

e20210080

Déclaration de conflit d'intérêts

Competing interests: The authors declare that they have no competing interests.

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Auteurs

Lawan Chanhome (L)

Snake Farm, Queen Saovabha Memorial Institute, The Thai Red Cross Society, Bangkok 10330, Thailand.

Orawan Khow (O)

Department of Research and Development, Queen Saovabha Memorial Institute, The Thai Red Cross Society, Bangkok 10330, Thailand.

Onrapak Reamtong (O)

Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.

Taksa Vasaruchapong (T)

Snake Farm, Queen Saovabha Memorial Institute, The Thai Red Cross Society, Bangkok 10330, Thailand.

Panithi Laoungbua (P)

Snake Farm, Queen Saovabha Memorial Institute, The Thai Red Cross Society, Bangkok 10330, Thailand.

Tanapong Tawan (T)

Snake Farm, Queen Saovabha Memorial Institute, The Thai Red Cross Society, Bangkok 10330, Thailand.

Sunutcha Suntrarachun (S)

Department of Research and Development, Queen Saovabha Memorial Institute, The Thai Red Cross Society, Bangkok 10330, Thailand.

Siravit Sitprija (S)

Department of Biology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.

Supeecha Kumkate (S)

Department of Biology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.

Narongsak Chaiyabutr (N)

Snake Farm, Queen Saovabha Memorial Institute, The Thai Red Cross Society, Bangkok 10330, Thailand.
Department of Research and Development, Queen Saovabha Memorial Institute, The Thai Red Cross Society, Bangkok 10330, Thailand.

Classifications MeSH