Intestinal Wnt in the transition from physiology to oncology.
Beta-catenin
Cell signaling
Colorectal cancer
Intestinal stem cells
Intestine
Wnt signaling
Journal
World journal of clinical oncology
ISSN: 2218-4333
Titre abrégé: World J Clin Oncol
Pays: United States
ID NLM: 101549149
Informations de publication
Date de publication:
24 Mar 2022
24 Mar 2022
Historique:
received:
23
02
2021
revised:
07
09
2021
accepted:
19
02
2022
entrez:
18
4
2022
pubmed:
19
4
2022
medline:
19
4
2022
Statut:
ppublish
Résumé
Adult stem cells are necessary for self-renewal tissues and regeneration after damage. Especially in the intestine, which self-renews every few days, they play a key role in tissue homeostasis. Therefore, complex regulatory mechanisms are needed to prevent hyperproliferation, which can lead in the worst case to carcinogenesis or under-activation of stem cells, which can result in dysfunctional epithelial. One main regulatory signaling pathway is the Wnt/β-catenin signaling pathway. It is a highly conserved pathway, with β-catenin, a transcription factor, as target protein. Translocation of β-catenin from cytoplasm to nucleus activates the transcription of numerous genes involved in regulating stem cell pluripo-tency, proliferation, cell differentiation and regulation of cell death. This review presents a brief overview of the Wnt/β-catenin signaling pathway, the regulatory mechanism of this pathway and its role in intestinal homeostasis. Additionally, this review highlights the molecular mechanisms and the histomorphological features of Wnt hyperactivation. Furthermore, the central role of the Wnt signaling pathway in intestinal carcinogenesis as well as its clinical relevance in colorectal carcinoma are discussed.
Identifiants
pubmed: 35433295
doi: 10.5306/wjco.v13.i3.168
pmc: PMC8966512
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
168-185Informations de copyright
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict-of-interest statement: The authors declare no conflicts of interest for this article.
Références
BMJ Open Gastroenterol. 2020 Jun;7(1):
pubmed: 32586946
Cancer Sci. 2018 Dec;109(12):4003-4014
pubmed: 30238564
Cell. 2002 Oct 18;111(2):251-63
pubmed: 12408869
Oncogene. 2016 Sep 8;35(36):4787-97
pubmed: 26876203
Gastroenterology. 2020 Dec;159(6):2163-2180.e6
pubmed: 32814111
Cancers (Basel). 2016 Jul 18;8(7):
pubmed: 27438855
EMBO J. 2019 Jan 15;38(2):
pubmed: 30425074
Comput Struct Biotechnol J. 2020 Jan 10;18:230-240
pubmed: 33489001
Am J Physiol Gastrointest Liver Physiol. 2014 Sep 1;307(5):G487-98
pubmed: 24994854
Am J Gastroenterol. 2005 Jun;100(6):1345-53
pubmed: 15929768
Annu Rev Physiol. 2013;75:289-311
pubmed: 23398152
Mol Ther. 2018 May 2;26(5):1287-1298
pubmed: 29606502
Oncotarget. 2014 May 30;5(10):2999-3011
pubmed: 24930890
Exp Mol Pathol. 2019 Feb;106:34-43
pubmed: 30539797
ChemMedChem. 2021 May 6;16(9):1420-1424
pubmed: 33275320
Crit Rev Oncol Hematol. 2016 Mar;99:141-9
pubmed: 26775730
Nat Commun. 2017 Jan 06;8:13824
pubmed: 28059064
PLoS One. 2011 Mar 18;6(3):e17957
pubmed: 21437251
Oncogene. 2011 Jun 9;30(23):2633-43
pubmed: 21317929
Nat Commun. 2019 Sep 18;10(1):4251
pubmed: 31534175
Nature. 2020 Feb;578(7795):437-443
pubmed: 32025032
Cancer Biol Ther. 2020;21(3):203-212
pubmed: 31747856
Development. 2000 Sep;127(17):3805-13
pubmed: 10934025
Development. 2012 Dec 1;139(23):4405-15
pubmed: 23132247
Genes Dev. 1994 Jan;8(1):118-30
pubmed: 8288125
Oncol Lett. 2020 Feb;19(2):1351-1367
pubmed: 31966067
Development. 2008 Feb;135(3):411-24
pubmed: 18192283
BMC Gastroenterol. 2008 Dec 02;8:57
pubmed: 19055726
Cell Stem Cell. 2020 Mar 5;26(3):391-402.e5
pubmed: 32084389
Dev Biol. 1976 Feb;48(2):461-5
pubmed: 815114
PLoS Comput Biol. 2017 Feb 28;13(2):e1005400
pubmed: 28245235
J Physiol. 2016 Sep 1;594(17):4791-803
pubmed: 26848053
Pol J Pathol. 2014 Dec;65(4):257-66
pubmed: 25693079
J Cell Physiol. 2018 Feb;233(2):811-817
pubmed: 28266708
Oncotarget. 2014 Feb 28;5(4):978-92
pubmed: 24657851
Biochem J. 2007 Mar 15;402(3):515-23
pubmed: 17117926
Mol Biol Cell. 2020 May 1;31(10):992-1014
pubmed: 32129710
Oncogene. 2004 Nov 4;23(52):8520-6
pubmed: 15378020
EMBO J. 2020 Feb 3;39(3):e102771
pubmed: 31867777
J Gastroenterol Hepatol. 2012 Oct;27(10):1629-34
pubmed: 22741528
Acta Physiol (Oxf). 2012 Jan;204(1):137-43
pubmed: 21439026
Gastroenterology. 2006 Jun;130(7):1941-9
pubmed: 16762617
Differentiation. 2019 Jul - Aug;108:24-32
pubmed: 30718056
Nat Rev Mol Cell Biol. 2021 Jan;22(1):39-53
pubmed: 32958874
EMBO J. 1999 Jan 4;18(1):188-97
pubmed: 9878062
J Biol Chem. 2010 Aug 13;285(33):25115-25
pubmed: 20551321
Int J Mol Sci. 2020 May 30;21(11):
pubmed: 32486158
Oncogene. 2008 Jul 24;27(32):4467-77
pubmed: 18408752
Development. 2020 Apr 12;147(8):
pubmed: 32156757
Oncogene. 2019 Mar;38(11):1951-1965
pubmed: 30390075
iScience. 2020 May 22;23(5):101076
pubmed: 32361596
Gastroenterology. 2009 Jan;136(1):196-205.e2
pubmed: 18951899
J Biol Chem. 2016 Mar 18;291(12):6569-82
pubmed: 26833564
J Cell Biol. 2004 Jul 5;166(1):37-47
pubmed: 15240568
Curr Opin Cell Biol. 2014 Dec;31:46-55
pubmed: 25200911
Nature. 2014 Jan 9;505(7482):180-5
pubmed: 24390349
Stem Cell Res Ther. 2020 Aug 12;11(1):349
pubmed: 32787930
Gastroenterology. 2005 Jun;128(7):1907-18
pubmed: 15940626
Biochem Biophys Res Commun. 2020 Mar 12;523(3):780-786
pubmed: 31952791
World J Gastroenterol. 2014 Oct 28;20(40):14855-64
pubmed: 25356045
Medicine (Baltimore). 2018 Dec;97(52):e13734
pubmed: 30593147
Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11717-22
pubmed: 22753465
EMBO J. 2019 Feb 15;38(4):
pubmed: 30635334
Dev Biol. 2015 Jun 1;402(1):98-108
pubmed: 25835502
Cancer Res. 2012 Mar 15;72(6):1547-56
pubmed: 22318865
Drug Dev Res. 2021 Dec;82(8):1182-1192
pubmed: 34002415
Mol Pharmacol. 2020 Feb;97(2):72-89
pubmed: 31787618
Lancet. 2003 Jul 19;362(9379):205-9
pubmed: 12885482
Sci Rep. 2020 Feb 19;10(1):2957
pubmed: 32076059
Nat Rev Cancer. 2008 Jun;8(6):415-24
pubmed: 18480839
Hum Pathol. 2009 Jun;40(6):872-80
pubmed: 19269007
BMC Genomics. 2014 Jan 28;15:74
pubmed: 24467841
Curr Biol. 2001 Jun 26;11(12):951-61
pubmed: 11448771
J Biol Chem. 2012 Apr 6;287(15):11730-9
pubmed: 22337891
J Crohns Colitis. 2017 Jun 1;11(6):649-670
pubmed: 28158501
Cell. 1990 Jun 1;61(5):759-67
pubmed: 2188735
Dev Cell. 2006 Dec;11(6):791-801
pubmed: 17141155
Cell. 2013 Jul 18;154(2):274-84
pubmed: 23870119
Br J Cancer. 2015 Sep 15;113(6):979-88
pubmed: 26305864
Oncogene. 2021 Jan;40(2):369-383
pubmed: 33144683
Cell Stem Cell. 2018 May 3;22(5):769-778.e4
pubmed: 29727683
J Biol Chem. 2010 Jan 1;285(1):392-400
pubmed: 19864427
Gastroenterology. 2020 Mar;158(4):985-999.e9
pubmed: 31759926
Genes Dev. 2018 Nov 1;32(21-22):1443-1458
pubmed: 30366904
Inflamm Bowel Dis. 2018 Aug 16;24(9):1895-1903
pubmed: 29668897
Cancer Cell Int. 2020 Dec 3;20(1):578
pubmed: 33292279
Oncogene. 2021 Feb;40(5):1027-1042
pubmed: 33323973
Life Sci Alliance. 2020 Dec 28;4(3):
pubmed: 33372038
Genes (Basel). 2018 Jan 08;9(1):
pubmed: 29316729
Biomedicines. 2019 Jun 19;7(2):
pubmed: 31248166
Cells. 2019 Aug 03;8(8):
pubmed: 31382613
Mol Carcinog. 2016 May;55(5):458-72
pubmed: 25808746
Annu Rev Physiol. 2009;71:241-60
pubmed: 18808327
Mol Med Rep. 2021 Feb;23(2):
pubmed: 33300082
Development. 2016 Feb 15;143(4):554-65
pubmed: 26884394
Nat Commun. 2020 Nov 13;11(1):5762
pubmed: 33188184
Int J Exp Pathol. 1997 Aug;78(4):219-43
pubmed: 9505935
Nature. 1999 Apr 1;398(6726):422-6
pubmed: 10201372
Nat Commun. 2020 Sep 15;11(1):4586
pubmed: 32934222
Sci Signal. 2020 Dec 01;13(660):
pubmed: 33262293
Nat Cell Biol. 2011 Aug 14;13(10):1244-51
pubmed: 21841793
Biomedicines. 2020 Dec 11;8(12):
pubmed: 33322272
Dev Cell. 2005 Apr;8(4):611-22
pubmed: 15809042
Infect Immun. 2012 Sep;80(9):3107-21
pubmed: 22710872
J Physiol. 2016 Sep 1;594(17):4837-47
pubmed: 27581568
Eur J Hum Genet. 2021 Jun;29(6):998-1007
pubmed: 33526876
Mod Pathol. 2001 Jan;14(1):29-39
pubmed: 11211307
Exp Biol Med (Maywood). 2017 Jun;242(11):1185-1197
pubmed: 28474989
Cell Death Differ. 2020 Oct;27(10):2872-2887
pubmed: 32355182
Genes Dev. 2003 Jul 15;17(14):1709-13
pubmed: 12865297
Mol Cancer. 2010 Sep 09;9:236
pubmed: 20828404
Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6315-20
pubmed: 19325125
J Cell Biol. 2007 Aug 13;178(4):635-48
pubmed: 17698607
J Biol Chem. 2009 Jun 12;284(24):16256-16263
pubmed: 19383605
Development. 2014 Jan;141(1):148-57
pubmed: 24284205
Adv Drug Deliv Rev. 2021 Feb;169:118-136
pubmed: 33346022
Cancer Discov. 2020 Oct;10(10):1590-1609
pubmed: 32546576
Cell Discov. 2020 Jun 9;6:35
pubmed: 32550000
Science. 1996 Mar 29;271(5257):1826-32
pubmed: 8596950
FEBS J. 2019 Oct;286(19):3745-3756
pubmed: 31342636
Nat Genet. 2004 Oct;36(10):1117-21
pubmed: 15378062
Nature. 2007 Oct 25;449(7165):1003-7
pubmed: 17934449
JAMA Oncol. 2017 Nov 01;3(11):1546-1553
pubmed: 28617917
Gene. 2009 Mar 1;432(1-2):112-7
pubmed: 19124064
Pharmacol Res. 2021 May;167:105532
pubmed: 33677106
Cell Death Dis. 2014 Jan 30;5:e1039
pubmed: 24481453
Curr Opin Cell Biol. 2007 Apr;19(2):166-75
pubmed: 17317139
Cell Res. 2005 Jan;15(1):28-32
pubmed: 15686623
Gastroenterology. 2012 Dec;143(6):1518-1529.e7
pubmed: 22922422
Gastroenterology. 2021 Feb;160(3):823-830
pubmed: 33217450
World J Exp Med. 2015 May 20;5(2):84-102
pubmed: 25992323
Oncogene. 2006 Dec 4;25(57):7482-91
pubmed: 17143292
Development. 2020 Sep 2;147(17):
pubmed: 32747435
Curr Gastroenterol Rep. 2010 Oct;12(5):340-8
pubmed: 20683682
Biochem Biophys Res Commun. 2017 Sep 16;491(2):469-477
pubmed: 28698142
Nat Rev Gastroenterol Hepatol. 2016 Jun;13(6):324-37
pubmed: 27147489
Cell Death Dis. 2019 Jan 10;10(1):26
pubmed: 30631044
Nature. 2011 Sep 18;478(7368):255-9
pubmed: 21927002
N Engl J Med. 2016 Jan 21;374(3):211-22
pubmed: 26789870
Development. 2012 Feb;139(3):465-74
pubmed: 22190642
Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15418-23
pubmed: 17881565
Development. 2011 Jun;138(12):2567-79
pubmed: 21610033
Science. 2010 Jan 29;327(5965):542-5
pubmed: 20110496
Int J Mol Sci. 2020 May 30;21(11):
pubmed: 32486243
Carcinogenesis. 2012 Mar;33(3):637-43
pubmed: 22198215
Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1603-8
pubmed: 9990071
Gut. 2020 Jun;69(6):1092-1103
pubmed: 31563876
Nat Chem Biol. 2018 Jun;14(6):582-590
pubmed: 29632413
J Biol Chem. 2008 Jul 11;283(28):19201-10
pubmed: 18487207
Nat Commun. 2020 Jan 17;11(1):334
pubmed: 31953387
Mol Cancer. 2009 Sep 24;8:76
pubmed: 19778454
Dev Biol. 2013 Jun 15;378(2):122-40
pubmed: 23570874
Life Sci. 2005 Jul 29;77(11):1249-62
pubmed: 15979100
Cancer Res. 2002 May 15;62(10):2744-8
pubmed: 12019147
Nat Cell Biol. 2001 Jul;3(7):683-6
pubmed: 11433302
Science. 1998 Sep 4;281(5382):1509-12
pubmed: 9727977
Cancers (Basel). 2019 Apr 18;11(4):
pubmed: 31003440
Carcinogenesis. 2006 Dec;27(12):2371-82
pubmed: 16728434
Cancer Res. 1994 Jul 1;54(13):3553-6
pubmed: 8012980
Cancer Biol Ther. 2016 May 3;17(5):558-65
pubmed: 27124543
Mol Cell Biol. 2002 Feb;22(4):1172-83
pubmed: 11809808
Am J Hum Genet. 2018 Jul 5;103(1):131-137
pubmed: 29909964
Major Probl Pathol. 1978;10:58-71
pubmed: 359943
Stem Cell Reports. 2016 Nov 8;7(5):826-839
pubmed: 27720905
Cell Mol Gastroenterol Hepatol. 2021;11(2):465-489
pubmed: 32971322
Noncoding RNA Res. 2018 Apr 12;3(2):42-53
pubmed: 30159439
Endoscopy. 2000 Mar;32(3):245-54
pubmed: 10718391
Development. 2020 Sep 15;147(18):
pubmed: 32878924
Nature. 2017 Jan 12;541(7636):182-187
pubmed: 28052057
Cancer Res. 2002 Sep 15;62(18):5126-8
pubmed: 12234972
Cold Spring Harb Perspect Biol. 2012 Dec 01;4(12):
pubmed: 23209147
Orphanet J Rare Dis. 2009 Oct 12;4:22
pubmed: 19822006