Epileptic seizures and link to memory processes.
Alzheimer's disease
epilepsy
extinction therapy
kindling
long-term potentiation
memory consolidation
reflex epilepsy
Journal
AIMS neuroscience
ISSN: 2373-7972
Titre abrégé: AIMS Neurosci
Pays: United States
ID NLM: 101665668
Informations de publication
Date de publication:
2022
2022
Historique:
received:
06
01
2022
revised:
17
02
2022
accepted:
01
03
2022
entrez:
18
4
2022
pubmed:
19
4
2022
medline:
19
4
2022
Statut:
epublish
Résumé
Epileptogenesis is a complex and not well understood phenomenon. Here, we explore the hypothesis that epileptogenesis could be "hijacking" normal memory processes, and how this hypothesis may provide new directions for epilepsy treatment. First, we review similarities between the hypersynchronous circuits observed in epilepsy and memory consolidation processes involved in strengthening neuronal connections. Next, we describe the kindling model of seizures and its relation to long-term potentiation model of synaptic plasticity. We also examine how the strengthening of epileptic circuits is facilitated during the physiological slow wave sleep, similarly as episodic memories. Furthermore, we present studies showing that specific memories can directly trigger reflex seizures. The neuronal hypersynchrony in early stages of Alzheimer's disease, and the use of anti-epileptic drugs to improve the cognitive symptoms in this disease also suggests a connection between memory systems and epilepsy. Given the commonalities between memory processes and epilepsy, we propose that therapies for memory disorders might provide new avenues for treatment of epileptic patients.
Identifiants
pubmed: 35434278
doi: 10.3934/Neuroscience.2022007
pii: neurosci-09-01-007
pmc: PMC8941196
doi:
Types de publication
Journal Article
Langues
eng
Pagination
114-127Informations de copyright
© 2022 the Author(s), licensee AIMS Press.
Déclaration de conflit d'intérêts
Conflict of interest: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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