Heat-induced SIRT1-mediated H4K16ac deacetylation impairs resection and SMARCAD1 recruitment to double strand breaks.
Biological sciences
Epigenetics
Molecular biology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
15 Apr 2022
15 Apr 2022
Historique:
received:
06
01
2022
revised:
16
02
2022
accepted:
21
03
2022
entrez:
18
4
2022
pubmed:
19
4
2022
medline:
19
4
2022
Statut:
epublish
Résumé
Hyperthermia inhibits DNA double-strand break (DSB) repair that utilizes homologous recombination (HR) pathway by a poorly defined mechanism(s); however, the mechanisms for this inhibition remain unclear. Here we report that hyperthermia decreases H4K16 acetylation (H4K16ac), an epigenetic modification essential for genome stability and transcription. Heat-induced reduction in H4K16ac was detected in humans,
Identifiants
pubmed: 35434547
doi: 10.1016/j.isci.2022.104142
pii: S2589-0042(22)00412-6
pmc: PMC9010620
doi:
Types de publication
Journal Article
Langues
eng
Pagination
104142Subventions
Organisme : NCI NIH HHS
ID : P01 CA104457
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA129537
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA154320
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM109768
Pays : United States
Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
Authors declare no competing interests.
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