Platelet-inspired nanomedicine in hemostasis thrombosis and thromboinflammation.
haemostasis
nanomedicine
platelets
thromboinflammation
thrombosis
Journal
Journal of thrombosis and haemostasis : JTH
ISSN: 1538-7836
Titre abrégé: J Thromb Haemost
Pays: England
ID NLM: 101170508
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
revised:
30
03
2022
received:
21
12
2021
accepted:
01
04
2022
pubmed:
19
4
2022
medline:
29
6
2022
entrez:
18
4
2022
Statut:
ppublish
Résumé
Platelets are anucleate cell-fragments derived predominantly from megakaryocytes in the bone marrow and released in the blood circulation, with a normal count of 150 000-40 000 per μl and a lifespan of approximately 10 days in humans. A primary role of platelets is to aid in vascular injury site-specific clot formation to stanch bleeding, termed hemostasis. Platelets render hemostasis by a complex concert of mechanisms involving platelet adhesion, activation and aggregation, coagulation amplification, and clot retraction. Additionally, platelet secretome can influence coagulation kinetics and clot morphology. Therefore, platelet defects and dysfunctions result in bleeding complications. Current treatment for such complications involve prophylactic or emergency transfusion of platelets. However, platelet transfusion logistics constantly suffer from limited donor availability, challenges in portability and storage, high bacterial contamination risks, and very short shelf life (~5 days). To address these issues, an exciting area of research is focusing on the development of microparticle- and nanoparticle-based platelet surrogate technologies that can mimic various hemostatic mechanisms of platelets. On the other hand, aberrant occurrence of the platelet mechanisms lead to the pathological manifestation of thrombosis and thromboinflammation. The treatments for this are focused on inhibiting the mechanisms or resolving the formed clots. Here, platelet-inspired technologies can provide unique platforms for disease-targeted drug delivery to achieve high therapeutic efficacy while avoiding systemic side-effects. This review will provide brief mechanistic insight into the role of platelets in hemostasis, thrombosis and thromboinflammation, and present the current state-of-art in the design of platelet-inspired nanomedicine for applications in these areas.
Identifiants
pubmed: 35435322
doi: 10.1111/jth.15734
pmc: PMC9323419
pii: S1538-7836(22)01925-0
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1535-1549Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL137695
Pays : United States
Organisme : British Heart Foundation
ID : FS/IBSRF/20/25039
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL141080
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL129179
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL121212
Pays : United States
Informations de copyright
© 2022 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis.
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