Moderate adiposity levels counteract protein metabolism modifications associated with aging in rats.
Aging
Amino acid digestibility
Obesity
Protein metabolism
Rat model
Journal
European journal of nutrition
ISSN: 1436-6215
Titre abrégé: Eur J Nutr
Pays: Germany
ID NLM: 100888704
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
received:
29
10
2021
accepted:
22
03
2022
pubmed:
19
4
2022
medline:
12
8
2022
entrez:
18
4
2022
Statut:
ppublish
Résumé
Physiological parameters such as adiposity and age are likely to influence protein digestion and utilization. The aim of this study was to evaluate the combined effects of age and adiposity on casein protein and amino acid true digestibility and its postprandial utilization in rats. Four groups were included (n = 7/8): 2 months/normal adiposity, 2 months/high adiposity, 11 months/normal adiposity and 11 months/high adiposity. Rats were given a calibrated meal containing Nitrogen and amino acid true digestibility of casein was around 95-96% depending on the group and was increased by 1% in high adiposity rats (P = 0.04). Higher adiposity levels counteracted the increase in total body deamination (P = 0.03) that was associated with older age. Significant effects of age (P = 0.006) and adiposity (P = 0.002) were observed in the muscle FSR, with age decreasing it and adiposity increasing it. This study revealed that a higher level of adiposity resulted in a slight increase in protein and individual amino acid true digestibility values and seemed to compensate for the metabolic postprandial protein alterations observed at older age.
Identifiants
pubmed: 35435502
doi: 10.1007/s00394-022-02881-4
pii: 10.1007/s00394-022-02881-4
doi:
Substances chimiques
Amino Acids
0
Caseins
0
Dietary Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3189-3200Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.
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