Microglia and Neurodevelopmental Disorders.
Rett syndrome
autism
microbiome
microglia
neurodevelopmental disorders
Journal
Annual review of neuroscience
ISSN: 1545-4126
Titre abrégé: Annu Rev Neurosci
Pays: United States
ID NLM: 7804039
Informations de publication
Date de publication:
08 07 2022
08 07 2022
Historique:
pubmed:
19
4
2022
medline:
14
7
2022
entrez:
18
4
2022
Statut:
ppublish
Résumé
Mounting evidence indicates that microglia, which are the resident immune cells of the brain, play critical roles in a diverse array of neurodevelopmental processes required for proper brain maturation and function. This evidence has ultimately led to growing speculation that microglial dysfunction may play a role in neurodevelopmental disorder (NDD) pathoetiology. In this review, we first provide an overview of how microglia mechanistically contribute to the sculpting of the developing brain and neuronal circuits. To provide an example of how disruption of microglial biology impacts NDD development, we also highlight emerging evidence that has linked microglial dysregulation to autism spectrum disorder pathogenesis. In recent years, there has been increasing interest in how the gut microbiome shapes microglial biology. In the last section of this review, we put a spotlight on this burgeoning area of microglial research and discuss how microbiota-dependent modulation of microglial biology is currently thought to influence NDD progression.
Identifiants
pubmed: 35436413
doi: 10.1146/annurev-neuro-110920-023056
pmc: PMC10449242
mid: NIHMS1901571
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
425-445Subventions
Organisme : NINDS NIH HHS
ID : R01 NS119243
Pays : United States
Organisme : NINDS NIH HHS
ID : K22 NS104392
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS106383
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS122782
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH120412
Pays : United States
Références
Glia. 2002 Nov;40(2):140-155
pubmed: 12379902
Microbiome. 2021 Jul 8;9(1):157
pubmed: 34238386
Nat Neurosci. 2013 May;16(5):543-51
pubmed: 23525041
Neuroscience. 2009 Feb 6;158(3):1030-8
pubmed: 18644426
Trends Neurosci. 2019 Nov;42(11):778-792
pubmed: 31635851
Neuron. 2017 May 17;94(4):759-773.e8
pubmed: 28521131
J Exp Med. 2019 Jan 7;216(1):41-59
pubmed: 30385457
J Pediatr Gastroenterol Nutr. 2010 Oct;51(4):418-24
pubmed: 20683204
Cell. 2016 Jun 16;165(7):1762-1775
pubmed: 27315483
Curr Top Dev Biol. 2015;114:159-84
pubmed: 26431567
Brain Commun. 2020 Oct 13;2(2):fcaa170
pubmed: 33241211
Dev Cell. 2015 Feb 23;32(4):478-90
pubmed: 25710534
Brain Stimul. 2019 Jan - Feb;12(1):19-29
pubmed: 30337243
Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16050-5
pubmed: 21876150
Dig Dis Sci. 2012 Aug;57(8):2096-102
pubmed: 22535281
Science. 2016 Feb 26;351(6276):933-9
pubmed: 26822608
Nat Neurosci. 2020 Sep;23(9):1055-1066
pubmed: 32632287
Acta Neuropathol. 2017 Sep;134(3):441-458
pubmed: 28685323
Nat Commun. 2016 Aug 25;7:12540
pubmed: 27558646
Cell. 2020 Jul 23;182(2):388-403.e15
pubmed: 32615087
Science. 2011 Sep 9;333(6048):1456-8
pubmed: 21778362
Science. 2018 Oct 12;362(6411):181-185
pubmed: 30309945
Dev Cell. 2015 Feb 23;32(4):469-77
pubmed: 25710533
Front Immunol. 2020 Mar 27;11:506
pubmed: 32292406
Neuron. 1998 Jan;20(1):35-41
pubmed: 9459440
Sci Rep. 2019 Apr 9;9(1):5821
pubmed: 30967657
Nat Rev Immunol. 2017 Apr;17(4):219-232
pubmed: 28260787
PLoS Biol. 2019 Oct 18;17(10):e3000492
pubmed: 31626642
Neuron. 2018 Oct 10;100(1):120-134.e6
pubmed: 30308165
J Inflamm (Lond). 2016 Oct 29;13:33
pubmed: 27807399
J Neurosci. 2004 Mar 3;24(9):2236-46
pubmed: 14999074
Cell. 2019 May 30;177(6):1600-1618.e17
pubmed: 31150625
EMBO J. 2020 Aug 17;39(16):e105380
pubmed: 32657463
Dialogues Clin Neurosci. 2017 Dec;19(4):335-343
pubmed: 29398929
Nat Neurosci. 2017 Oct;20(10):1371-1376
pubmed: 28846081
Mol Autism. 2017 Mar 29;8:17
pubmed: 28367307
Immunity. 2018 May 15;48(5):979-991.e8
pubmed: 29752066
J Neurosci. 2013 Mar 6;33(10):4216-33
pubmed: 23467340
Neuron. 2019 Mar 20;101(6):998-1002
pubmed: 30897366
J Autism Dev Disord. 2012 Dec;42(12):2569-84
pubmed: 22466688
Cell. 2013 Dec 19;155(7):1596-609
pubmed: 24360280
J Neurochem. 2017 Dec 21;:
pubmed: 29266221
J Neuroinflammation. 2016 May 10;13(1):103
pubmed: 27165310
Nature. 2016 Apr 14;532(7598):240-244
pubmed: 27049947
J Neurosci. 2008 Aug 6;28(32):8138-43
pubmed: 18685038
Front Neural Circuits. 2019 Aug 28;13:55
pubmed: 31555101
Behav Brain Res. 2017 Aug 14;332:110-119
pubmed: 28506622
Nat Commun. 2013;4:1484
pubmed: 23403561
Nat Rev Neurosci. 2015 Dec;16(12):756-67
pubmed: 26585800
Biol Psychiatry. 2020 Sep 15;88(6):488-499
pubmed: 32418612
J Neurosci. 2012 Dec 12;32(50):18009-17, 18017a
pubmed: 23238717
Arch Gen Psychiatry. 2000 Jan;57(1):65-73
pubmed: 10632234
Cell. 2020 Aug 6;182(3):625-640.e24
pubmed: 32702313
Cell Metab. 2021 Nov 2;33(11):2260-2276.e7
pubmed: 34731656
Annu Rev Neurosci. 2018 Jul 8;41:61-76
pubmed: 29986163
Autism Res. 2016 Jul;9(7):752-9
pubmed: 26437875
Nat Neurosci. 2019 Mar;22(3):374-385
pubmed: 30718903
Science. 2018 Mar 16;359(6381):1269-1273
pubmed: 29420261
Nature. 2017 Sep 28;549(7673):528-532
pubmed: 28902840
Nat Neurosci. 2013 Dec;16(12):1896-905
pubmed: 24162652
Am Fam Physician. 2016 Dec 15;94(12):972-979
pubmed: 28075089
Neuron. 2014 Sep 3;83(5):1073-1084
pubmed: 25132466
Nat Neurosci. 2014 Jan;17(1):131-43
pubmed: 24316888
Neurogastroenterol Motil. 2011 Dec;23(12):1132-9
pubmed: 21988661
Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7975-80
pubmed: 20375278
Science. 2010 Nov 5;330(6005):841-5
pubmed: 20966214
Neuron. 2004 Feb 19;41(4):535-47
pubmed: 14980203
Cell. 2018 Jan 25;172(3):500-516.e16
pubmed: 29275859
Nat Med. 2016 Apr;22(4):345-61
pubmed: 27050589
Nature. 2020 Apr;580(7805):647-652
pubmed: 32350463
Nat Neurosci. 2015 Jul;18(7):965-77
pubmed: 26030851
Cell. 2016 Dec 1;167(6):1469-1480.e12
pubmed: 27912057
Nat Neurosci. 2011 Jul 31;14(9):1142-9
pubmed: 21804537
Immunol Rev. 2012 Jan;245(1):164-76
pubmed: 22168419
Cell. 2007 Dec 14;131(6):1164-78
pubmed: 18083105
Nat Rev Immunol. 2021 Jul;21(7):454-468
pubmed: 33479477
Biol Psychiatry. 2013 Sep 15;74(6):427-35
pubmed: 23790226
Nat Neurosci. 2007 Dec;10(12):1538-43
pubmed: 18026097
Nature. 2020 Oct;586(7828):281-286
pubmed: 32968276
Science. 2016 Aug 19;353(6301):772-7
pubmed: 27540164
Nat Commun. 2018 Mar 26;9(1):1228
pubmed: 29581545
Neurosci Lett. 2016 Apr 21;619:114-20
pubmed: 26971699
MMWR Surveill Summ. 2020 Mar 27;69(4):1-12
pubmed: 32214087
Elife. 2017 Dec 18;6:
pubmed: 29251592
Nat Rev Neurosci. 2015 Aug;16(8):469-86
pubmed: 26189694
Annu Rev Immunol. 2020 Apr 26;38:597-620
pubmed: 32340575
Annu Rev Pharmacol Toxicol. 2020 Jan 6;60:477-502
pubmed: 31506009
Mol Psychiatry. 2021 Jun;26(6):1808-1831
pubmed: 32071385
Int J Mol Sci. 2020 Sep 12;21(18):
pubmed: 32932690
Nature. 2012 Mar 18;484(7392):105-9
pubmed: 22425995
J Neurosci. 2021 Feb 10;41(6):1274-1287
pubmed: 33380470
Exp Neurol. 2018 Jan;299(Pt A):241-251
pubmed: 28698032
PLoS One. 2013;8(2):e56293
pubmed: 23393609
PLoS One. 2013 Nov 22;8(11):e81218
pubmed: 24278397
Neuron. 2019 Jan 16;101(2):246-259.e6
pubmed: 30522820
Neuron. 2018 Jun 27;98(6):1170-1183.e8
pubmed: 29861285
J Exp Med. 2019 Jul 1;216(7):1542-1560
pubmed: 31097468
Science. 2016 Aug 19;353(6301):aad8670
pubmed: 27338705
EMBO J. 2020 Aug 17;39(16):e104136
pubmed: 32452062
Nat Commun. 2020 Apr 14;11(1):1797
pubmed: 32286273
Autism Res. 2021 Sep;14(9):1820-1836
pubmed: 34173726
J Exp Med. 2018 Jun 4;215(6):1627-1647
pubmed: 29643186
Nat Neurosci. 2005 Jun;8(6):752-8
pubmed: 15895084
Brain Sci. 2020 Apr 13;10(4):
pubmed: 32294927
Behav Brain Res. 2017 Jul 28;331:92-101
pubmed: 28499914
Nat Commun. 2016 Mar 07;7:10905
pubmed: 26948129
Science. 2019 May 17;364(6441):685-689
pubmed: 31097668
Biol Psychiatry. 2010 Aug 15;68(4):368-76
pubmed: 20674603
eNeuro. 2019 Aug 26;6(4):
pubmed: 31371457
J Autism Dev Disord. 2014 May;44(5):1117-27
pubmed: 24193577
Cell Rep. 2017 Jul 25;20(4):779-784
pubmed: 28746864
Nat Rev Immunol. 2021 Aug;21(8):526-541
pubmed: 33649606
Glia. 2014 Mar;62(3):399-410
pubmed: 24357027
Anat Sci Int. 2004 Dec;79(4):191-7
pubmed: 15633457
Mol Psychiatry. 2020 May;25(5):1050-1067
pubmed: 31772304
Glia. 2013 Oct;61(10):1582-94
pubmed: 23893820
Mol Psychiatry. 2007 Mar;12(3):292-306
pubmed: 17189958
Sci Transl Med. 2018 Dec 12;10(471):
pubmed: 30541786
Front Neuroanat. 2014 Sep 10;8:97
pubmed: 25309341
PLoS One. 2013 Oct 09;8(10):e76993
pubmed: 24130822
Cell. 2013 Dec 19;155(7):1451-63
pubmed: 24315484
Brain Res. 2010 Jan 14;1309:83-94
pubmed: 19896929
J Immunol. 2018 Aug 1;201(3):845-850
pubmed: 29967099
Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):7071-7076
pubmed: 30890637
Nature. 2014 Dec 11;516(7530):246-9
pubmed: 25274309
Cold Spring Harb Perspect Med. 2020 Mar 2;10(3):
pubmed: 31138538
Cell Rep. 2020 Aug 18;32(7):108047
pubmed: 32814050
Nat Neurosci. 2014 Mar;17(3):400-6
pubmed: 24487234
Brain. 2009 Feb;132(Pt 2):288-95
pubmed: 18567623
Neuromolecular Med. 2014 Jun;16(2):231-64
pubmed: 24615633
Neuropsychopharmacology. 2016 Aug;41(9):2206-14
pubmed: 26868058
Prog Neurobiol. 2019 Apr;175:1-19
pubmed: 30590095
J Neuroimmune Pharmacol. 2013 Jun;8(3):494-509
pubmed: 23354784
Front Cell Neurosci. 2019 Aug 20;13:385
pubmed: 31481879
Neuron. 2017 Nov 1;96(3):697-708
pubmed: 29096081
Brain Behav Immun. 2017 Jul;63:88-98
pubmed: 27697456
Dev Neurobiol. 2017 Jun;77(6):753-766
pubmed: 27706925
Neuron. 2012 May 24;74(4):691-705
pubmed: 22632727
Immunity. 2015 Apr 21;42(4):679-91
pubmed: 25902482
Free Radic Biol Med. 2020 May 20;152:100-106
pubmed: 32119978
Brain Behav Immun. 2017 Feb;60:106-116
pubmed: 26883520
Exp Oncol. 2012 Oct;34(3):146-52
pubmed: 23069998
Transl Psychiatry. 2020 Jun 9;10(1):186
pubmed: 32518376