Norovirus 3C-Like protease antagonizes interferon-β production by cleaving NEMO.

Antiviral Agents Cysteine Endopeptidases Humans Interferon-beta / genetics Interferons / genetics Norovirus / genetics Peptide Hydrolases
3C-like protease Interferon-β NEMO Norovirus

Journal

Virology
ISSN: 1096-0341
Titre abrégé: Virology
Pays: United States
ID NLM: 0110674

Informations de publication

Date de publication:
06 2022
Historique:
received: 13 01 2022
revised: 06 04 2022
accepted: 07 04 2022
pubmed: 19 4 2022
medline: 18 5 2022
entrez: 18 4 2022
Statut: ppublish

Résumé

An epidemic owing to Norovirus (NoV) has recently been occurring worldwide. Severe cases of NoV can lead to patient death, resulting in significant public health problems. In the early stages of infection, antagonizing the production of host interferon (IFN) is an important strategy for viruses to establish infection. However, the relationship between NoV and interferon and its mechanism remains unclear. In this study, the 3C-like protease encoded by NoV was found to effectively suppress Sendai virus (SEV)-mediated IFN-β production by cleaving the NF-κB essential modulator (NEMO). Glutamine 205 is the site of NoV3CL

Identifiants

DOI: 10.1016/j.virol.2022.04.004 PMID: 35436639
pubmed: 35436639
pii: S0042-6822(22)00062-9
doi: 10.1016/j.virol.2022.04.004
pii:
doi:

Substances chimiques

Antiviral Agents 0
Interferon-beta 77238-31-4
Interferons 9008-11-1
Peptide Hydrolases EC 3.4.-
Cysteine Endopeptidases EC 3.4.22.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

12-20

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Auteurs

Huan Zhang (H)

Key Laboratory of Livestock Infectious Diseases, Ministry of Education, Shenyang Agricultural University, Shenyang, 110866, China.

Pengfei Jiang (P)

Key Laboratory of Livestock Infectious Diseases, Ministry of Education, Shenyang Agricultural University, Shenyang, 110866, China.

Zeliang Chen (Z)

Key Laboratory of Livestock Infectious Diseases, Ministry of Education, Shenyang Agricultural University, Shenyang, 110866, China.

Dang Wang (D)

State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, China.

Yanrong Zhou (Y)

State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, China.

Xinyu Zhu (X)

State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, China.

Shaobo Xiao (S)

State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, China.

Liurong Fang (L)

State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, China. Electronic address: fanglr@mail.hzau.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Norovirus 3C-Like protease antagonizes...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Endopeptidases › Cysteine endopeptidases › Norovirus 3C-Like protease antagonizes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Norovirus 3C-Like protease antagonizes...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interférons › Interféron de type I › Interféron bêta › Norovirus 3C-Like protease antagonizes...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interférons › Norovirus 3C-Like protease antagonizes...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Caliciviridae › Norovirus › Norovirus 3C-Like protease antagonizes...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Norovirus 3C-Like protease antagonizes...