Leveraging electronic patient diaries in SUDEP risk evaluation.


Journal

Epilepsy research
ISSN: 1872-6844
Titre abrégé: Epilepsy Res
Pays: Netherlands
ID NLM: 8703089

Informations de publication

Date de publication:
05 2022
Historique:
received: 26 10 2021
revised: 19 03 2022
accepted: 08 04 2022
pubmed: 19 4 2022
medline: 29 4 2022
entrez: 18 4 2022
Statut: ppublish

Résumé

Our aim was to describe the risk factors known to be related to sudden unexpected death in epilepsy (SUDEP) that can be extracted from patients that utilizes an online seizure diary tool (SeizureTracker™). We conducted a descriptive analysis of SeizureTracker™ users across factors relevant to SUDEP risk. We also compared our app-using cohort to published SUDEP case-control studies. We report across seven risk factors from 30,813 users of SeizureTracker™ who had a median length of time using the app of 5.69 years (range from 1 month to 15 years). We found that they are at greater risk for SUDEP than groups from published studies (p < .00001) based on the risk factor of generalized tonic-clonic seizures. We demonstrated that the population using the SeizureTracker™ tool can be a valuable population for expanding investigation of SUDEP risk factors and is a first step towards establishing a large sample with a method to ascertain data prospectively that might be critical to developing a SUDEP risk algorithm.

Identifiants

pubmed: 35436674
pii: S0920-1211(22)00075-4
doi: 10.1016/j.eplepsyres.2022.106924
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

106924

Informations de copyright

Copyright © 2022 Elsevier B.V. All rights reserved.

Auteurs

Madison M Berl (MM)

Children's National Research Institute, Children's National Hospital, USA. Electronic address: mberl@childrensnational.org.

Robert Moss (R)

Seizure Tracker, USA.

Adrian Bumbut (A)

Children's National Research Institute, Children's National Hospital, USA.

Elizabeth J Donner (EJ)

Hospital for Sick Children, University of Toronto, Canada.

William D Gaillard (WD)

Children's National Research Institute, Children's National Hospital, USA.

Howard P Goodkin (HP)

University of Virginia, USA.

Zachary M Grinspan (ZM)

Weill Cornell Medicine, USA.

Barbara L Kroner (BL)

RTI International, USA.

Juma Mbwana (J)

Children's National Research Institute, Children's National Hospital, USA.

Anup D Patel (AD)

Nationwide Children's Hospital, USA.

Gardiner Lapham (G)

Children's National Research Institute, Children's National Hospital, USA.

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Classifications MeSH