Pulmonary perfusion imaging and delayed imaging to measure pulmonary capillary permeability in pulmonary contusion.
Journal
Nuclear medicine communications
ISSN: 1473-5628
Titre abrégé: Nucl Med Commun
Pays: England
ID NLM: 8201017
Informations de publication
Date de publication:
01 Jun 2022
01 Jun 2022
Historique:
pubmed:
20
4
2022
medline:
18
5
2022
entrez:
19
4
2022
Statut:
ppublish
Résumé
Explore the application value of pulmonary perfusion imaging and delayed imaging for evaluating pulmonary capillary permeability. After establishing a rat model of pulmonary contusion, changes in the metabolic index of technetium-99m macroaggregated albumin (99mTC-MAA) in the lungs of model rats were evaluated for two consecutive days. 99mTC-MAA metabolic indices of rat lungs with pulmonary contusion of varying severity (mild, moderate, and severe) were correlated with lung wet/dry weight ratio (W/D) and Evans blue extravasation. Finally, the method was validated in patients with pulmonary contusion and one healthy volunteer. The 99mTC-MAA metabolic index was 23.56% ± 2.44% in healthy control (HC) rat lung, 8.56% ± 3.42% immediately after lung contusion (d0), 8.35% ± 3.20% after 1 day (d1), and 17.45% ± 6.44% after 2 days (d2); indices at d0 and d1 were significantly higher than those at HC (P < 0.05). The metabolic index of 99mTC-MAA in lung had significant negative correlations with W/D (r = -0.8025; P = 0.0092) and Evans blue extravasation (r = -0.9356; P = 0.0002). Metabolic and oxygenation indices of 99mTC-MAA exhibited a significant positive linear correlation in patients with pulmonary contusion (r = 0.8925; P = 0.0416). Pulmonary perfusion and delayed imaging of 99mTC-MAA have potential value for evaluating pulmonary capillary permeability.
Identifiants
pubmed: 35437294
doi: 10.1097/MNM.0000000000001560
pii: 00006231-202206000-00010
doi:
Substances chimiques
Technetium Tc 99m Aggregated Albumin
0
Evans Blue
45PG892GO1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
687-693Informations de copyright
Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc.
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