Body mass index associated with monoclonal gammopathy of undetermined significance (MGUS) progression in Olmsted County, Minnesota.


Journal

Blood cancer journal
ISSN: 2044-5385
Titre abrégé: Blood Cancer J
Pays: United States
ID NLM: 101568469

Informations de publication

Date de publication:
19 04 2022
Historique:
received: 26 11 2021
accepted: 22 02 2022
revised: 16 02 2022
entrez: 20 4 2022
pubmed: 21 4 2022
medline: 22 4 2022
Statut: epublish

Résumé

Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant clonal disorder that progresses to multiple myeloma (MM), or other plasma-cell or lymphoid disorders at a rate of 1%/year. We evaluate the contribution of body mass index (BMI) to MGUS progression beyond established clinical factors in a population-based study. We identified 594 MGUS through a population-based screening study in Olmsted County, Minnesota, between 1995 and 2003. Follow-up time was calculated from the date of MGUS to last follow-up, death, or progression to MM/another plasma-cell/lymphoid disorder. BMI (kg/m

Identifiants

pubmed: 35440099
doi: 10.1038/s41408-022-00659-9
pii: 10.1038/s41408-022-00659-9
pmc: PMC9018764
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

67

Subventions

Organisme : NCI NIH HHS
ID : P30 CA015083
Pays : United States

Informations de copyright

© 2022. The Author(s).

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Auteurs

Geffen Kleinstern (G)

School of Public Health, University of Haifa, Haifa, Israel.
Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.

Dirk R Larson (DR)

Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.

Cristine Allmer (C)

Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.

Aaron D Norman (AD)

Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.

Grace Muntifering (G)

University of Wisconsin, La Crosse, WI, USA.

Jason Sinnwell (J)

Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.

Alissa Visram (A)

Department of Medicine, Division of Hematology, Mayo Clinic, Rochester, MN, USA.
The Ottawa Hospital, Ottawa Hospital Research Institute, Ottawa, ON, Canada.

Vincent Rajkumar (V)

Department of Medicine, Division of Hematology, Mayo Clinic, Rochester, MN, USA.

Angela Dispenzieri (A)

Department of Medicine, Division of Hematology, Mayo Clinic, Rochester, MN, USA.

Robert A Kyle (RA)

Department of Medicine, Division of Hematology, Mayo Clinic, Rochester, MN, USA.

Susan L Slager (SL)

Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Department of Medicine, Division of Hematology, Mayo Clinic, Rochester, MN, USA.

Shaji Kumar (S)

Department of Medicine, Division of Hematology, Mayo Clinic, Rochester, MN, USA.

Celine M Vachon (CM)

Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA. vachon.celine@mayo.edu.

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