Boron encapsulated in a liposome can be used for combinational neutron capture therapy.

Boron / therapeutic use Boron Compounds Boron Neutron Capture Therapy / methods Copper Radioisotopes Humans Liposomes Neoplasms / diagnostic imaging Penicillins

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
19 04 2022
Historique:
received: 09 11 2021
accepted: 31 03 2022
entrez: 20 4 2022
pubmed: 21 4 2022
medline: 22 4 2022
Statut: epublish

Résumé

Boron neutron capture therapy (BNCT) is an attractive approach to treat invasive malignant tumours due to binary heavy-particle irradiation, but its clinical applications have been hindered by boron delivery agents with low in vivo stability, poor biocompatibility, and limited application of combinational modalities. Here, we report boronsome, a carboranyl-phosphatidylcholine based liposome for combinational BNCT and chemotherapy. Theoretical simulations and experimental approaches illustrate high stability of boronsome. Then positron emission tomography (PET) imaging with Cu-64 labelled boronsome reveals high-specific tumour accumulation and long retention with a clear irradiation background. In particular, we show the suppression of tumour growth treated with boronsome with neutron irradiation and therapeutic outcomes are further improved by encapsulation of chemotherapy drugs, especially with PARP1 inhibitors. In sum, boronsome may be an efficient agent for concurrent chemoradiotherapy with theranostic properties against malignancies.

Identifiants

DOI: 10.1038/s41467-022-29780-w PMID: 35440126 PMC: PMC9018847
pubmed: 35440126
doi: 10.1038/s41467-022-29780-w
pii: 10.1038/s41467-022-29780-w
pmc: PMC9018847
doi:

Substances chimiques

Boron Compounds 0
Copper Radioisotopes 0
Copper-64 0
Liposomes 0
Penicillins 0
Boron N9E3X5056Q

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2143

Informations de copyright

© 2022. The Author(s).

Références

Angew Chem Int Ed Engl. 2019 Feb 25;58(9):2570-2579
pubmed: 29968300
Cancer Treat Rev. 2010 Nov;36(7):566-75
pubmed: 20409643
Nat Rev Drug Discov. 2020 Oct;19(10):711-736
pubmed: 32884152
Bioconjug Chem. 2019 Nov 20;30(11):2870-2878
pubmed: 31593447
Basic Life Sci. 1989;50:251-60
pubmed: 2665729
J Neurooncol. 2003 Mar-Apr;62(1-2):187-95
pubmed: 12749713
ACS Appl Mater Interfaces. 2018 Dec 19;10(50):43387-43395
pubmed: 30451482
Chin J Cancer Res. 2016 Dec;28(6):634-640
pubmed: 28174492
Nat Mater. 2011 Apr;10(4):324-32
pubmed: 21423187
Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6512-7
pubmed: 23536304
Bioconjug Chem. 2013 Jan 16;24(1):124-32
pubmed: 23214414
Eur Biophys J. 2011 Jul;40(7):843-56
pubmed: 21533652
J Chem Theory Comput. 2010 Jan 12;6(1):325-36
pubmed: 26614341
Pharm Res. 2019 Aug 7;36(10):144
pubmed: 31392417
Chem Rev. 2021 Oct 27;121(20):12181-12277
pubmed: 34279087
Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1367-70
pubmed: 7877984
Chem Commun (Camb). 2004 Sep 7;(17):1910-1
pubmed: 15340596
J Nucl Med. 1998 Feb;39(2):325-33
pubmed: 9476945
Chemistry. 2020 Nov 2;26(61):13832-13841
pubmed: 32521076
Mol Pharm. 2018 Oct 1;15(10):4426-4433
pubmed: 30133286
Nat Commun. 2014 Apr 03;5:3546
pubmed: 24699423
EJNMMI Res. 2016 Dec;6(1):75
pubmed: 27757932
Nat Chem Biol. 2011 Sep 18;7(11):763-5
pubmed: 21926997
Chem Rev. 2011 Nov 9;111(11):7035-62
pubmed: 21780840
Cancer Commun (Lond). 2018 Jun 19;38(1):35
pubmed: 29914561
Nat Protoc. 2006;1(5):2315-9
pubmed: 17406473
Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16077-81
pubmed: 25349432
Small. 2010 Apr 23;6(8):952-9
pubmed: 20333693
Clin Cancer Res. 2005 Jun 1;11(11):3987-4002
pubmed: 15930333
Small. 2016 Jun;12(22):3039-47
pubmed: 27121003
Radiat Oncol. 2012 Aug 29;7:146
pubmed: 22929110
Chem Rev. 2011 Sep 14;111(9):5701-22
pubmed: 21718011
Dalton Trans. 2010 Feb 21;39(7):1817-22
pubmed: 20449427
Bioconjug Chem. 2006 Sep-Oct;17(5):1314-20
pubmed: 16984142
Chem Rev. 1998 Jun 18;98(4):1515-1562
pubmed: 11848941
Cancer Res. 1990 Feb 15;50(4):1061-70
pubmed: 2404588
J Control Release. 2004 Aug 11;98(2):195-207
pubmed: 15262412
Bioconjug Chem. 2006 Jan-Feb;17(1):15-20
pubmed: 16417247
J Comput Aided Mol Des. 2014 Mar;28(3):221-33
pubmed: 24477799

Auteurs

Jiyuan Li (J)

Beijing National Laboratory for Molecular Sciences, Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.

Qi Sun (Q)

Peking University-Tsinghua University Center for Life Sciences, Beijing, 100871, China.

Chuanjie Lu (C)

Beijing National Laboratory for Molecular Sciences, Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.

Han Xiao (H)

University of Chinese Academy of Sciences Beijing, Beijing, 100049, China.

Zhibin Guo (Z)

Beijing National Laboratory for Molecular Sciences, Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.

Dongban Duan (D)

Beijing National Laboratory for Molecular Sciences, Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.

Zizhu Zhang (Z)

Beijing Nuclear Industry Hospital, Beijing, 100045, China.
Beijing Capture Tech Co., Ltd, Beijing, 102413, China.

Tong Liu (T)

Beijing Capture Tech Co., Ltd, Beijing, 102413, China.

Zhibo Liu (Z)

Beijing National Laboratory for Molecular Sciences, Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China. zbliu@pku.edu.cn.
Peking University-Tsinghua University Center for Life Sciences, Beijing, 100871, China. zbliu@pku.edu.cn.
ORCID: 0000-0002-5587-4165

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Classifications MeSH

questionsmedicales.fr › Produits chimiques inorganiques › Éléments › Métalloïdes › Bore › Boron encapsulated in a liposome can be used...
questionsmedicales.fr › Composés chimiques organiques › Composés du bore › Boron encapsulated in a liposome can be used...
questionsmedicales.fr › Thérapeutique › Radiothérapie › Radiothérapie de haute énergie › Thérapie par capture de neutrons › Thérapie par capture de neutrons par le bore › Boron encapsulated in a liposome can be used...
questionsmedicales.fr › Produits chimiques inorganiques › Isotopes › Radio-isotopes › Radio-isotopes du cuivre › Boron encapsulated in a liposome can be used...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Boron encapsulated in a liposome can be used...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomimétiques › Membrane artificielle › Liposomes › Boron encapsulated in a liposome can be used...
questionsmedicales.fr › Tumeurs › Boron encapsulated in a liposome can be used...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Pénicillines › Boron encapsulated in a liposome can be used...