Spontaneous variability in gamma dynamics described by a damped harmonic oscillator driven by noise.


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
19 04 2022
Historique:
received: 19 05 2020
accepted: 14 03 2022
entrez: 20 4 2022
pubmed: 21 4 2022
medline: 22 4 2022
Statut: epublish

Résumé

Circuits of excitatory and inhibitory neurons generate gamma-rhythmic activity (30-80 Hz). Gamma-cycles show spontaneous variability in amplitude and duration. To investigate the mechanisms underlying this variability, we recorded local-field-potentials (LFPs) and spikes from awake macaque V1. We developed a noise-robust method to detect gamma-cycle amplitudes and durations, which showed a weak but positive correlation. This correlation, and the joint amplitude-duration distribution, is well reproduced by a noise-driven damped harmonic oscillator. This model accurately fits LFP power-spectra, is equivalent to a linear, noise-driven E-I circuit, and recapitulates two additional features of gamma: (1) Amplitude-duration correlations decrease with oscillation strength; (2) amplitudes and durations exhibit strong and weak autocorrelations, respectively, depending on oscillation strength. Finally, longer gamma-cycles are associated with stronger spike-synchrony, but lower spike-rates in both (putative) excitatory and inhibitory neurons. In sum, V1 gamma-dynamics are well described by the simplest possible model of gamma: A damped harmonic oscillator driven by noise.

Identifiants

pubmed: 35440540
doi: 10.1038/s41467-022-29674-x
pii: 10.1038/s41467-022-29674-x
pmc: PMC9018758
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2019

Informations de copyright

© 2022. The Author(s).

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Auteurs

Georgios Spyropoulos (G)

Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, 60528, Frankfurt, Germany. georgios.spyropoulos@esi-frankfurt.de.

Matteo Saponati (M)

Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, 60528, Frankfurt, Germany.
International Max Planck Research School for Neural Circuits, Frankfurt Am Main, Germany.

Jarrod Robert Dowdall (JR)

Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, 60528, Frankfurt, Germany.
International Max Planck Research School for Neural Circuits, Frankfurt Am Main, Germany.

Marieke Louise Schölvinck (ML)

Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, 60528, Frankfurt, Germany.

Conrado Arturo Bosman (CA)

Donders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 EN, Nijmegen, the Netherlands.
Swammerdam Institute for Life Sciences, Center for Neuroscience, Faculty of Science, University of Amsterdam, 1098 XH, Amsterdam, the Netherlands.

Bruss Lima (B)

Max Planck Institute for Brain Research, 60438, Frankfurt, Germany.
Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro, Brazil.

Alina Peter (A)

Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, 60528, Frankfurt, Germany.
International Max Planck Research School for Neural Circuits, Frankfurt Am Main, Germany.

Irene Onorato (I)

Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, 60528, Frankfurt, Germany.
International Max Planck Research School for Neural Circuits, Frankfurt Am Main, Germany.

Johanna Klon-Lipok (J)

Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, 60528, Frankfurt, Germany.
Max Planck Institute for Brain Research, 60438, Frankfurt, Germany.

Rasmus Roese (R)

Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, 60528, Frankfurt, Germany.

Sergio Neuenschwander (S)

Max Planck Institute for Brain Research, 60438, Frankfurt, Germany.
Brain Institute, Federal University of Rio Grande do Norte, 59056-450, Natal, Brazil.

Pascal Fries (P)

Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, 60528, Frankfurt, Germany. pascal.fries@esi-frankfurt.de.
Donders Institute for Brain, Cognition and Behaviour, Radboud University, 6525 EN, Nijmegen, the Netherlands. pascal.fries@esi-frankfurt.de.

Martin Vinck (M)

Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, 60528, Frankfurt, Germany. martin.vinck@esi-frankfurt.de.
Donders Centre for Neuroscience, Department of Neuroinformatics, Radboud University, 6525 EN, Nijmegen, the Netherlands. martin.vinck@esi-frankfurt.de.

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