Pulmonary Manifestations of Primary Humoral Deficiencies.
Journal
Canadian respiratory journal
ISSN: 1916-7245
Titre abrégé: Can Respir J
Pays: Egypt
ID NLM: 9433332
Informations de publication
Date de publication:
2022
2022
Historique:
received:
12
02
2022
revised:
16
03
2022
accepted:
25
03
2022
entrez:
20
4
2022
pubmed:
21
4
2022
medline:
22
4
2022
Statut:
epublish
Résumé
Primary immunodeficiencies are a group of conditions characterized by developmental or functional alterations in the immune system caused by hereditary genetic defects. Primary immunodeficiencies may affect either the innate or the adaptive (humoral and cellular) immune system. Pulmonary complications in primary humoral deficiencies are frequent and varied and are associated with high morbidity and mortality rates. The types of complications include bronchiectasis secondary to recurrent respiratory infections and interstitial pulmonary involvement, which can be associated with autoimmune cytopenias, lymphoproliferation, and a range of immunological manifestations. Early detection is key to timely management. Immunoglobulin replacement therapy reduces the severity of disease, the frequency of exacerbations, and hospital admissions in some primary humoral deficiencies. Therefore, the presence of pulmonary disease with concomitant infectious and/or autoimmune complications should raise suspicion of primary humoral deficiencies and warrants a request for immunoglobulin determination in blood. Once diagnosis is confirmed; early immunoglobulin replacement therapy will improve the course of the disease. Further studies are needed to better understand the pathogenesis of pulmonary disease related to primary humoral deficiencies and favor the development of targeted therapies that improve the prognosis of patients.
Identifiants
pubmed: 35440951
doi: 10.1155/2022/7140919
pmc: PMC9013573
doi:
Substances chimiques
Immunoglobulins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
7140919Informations de copyright
Copyright © 2022 Ana Casal et al.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest associated with this publication. This project did not receive financial support that could have influenced its outcome.
Références
Thorax. 1992 Apr;47(4):323-4
pubmed: 1585301
Curr Opin Allergy Clin Immunol. 2012 Dec;12(6):602-8
pubmed: 23026772
Radiographics. 2016 Jan-Feb;36(1):53-70
pubmed: 26761531
Pharmacol Ther. 2014 Aug;143(2):225-45
pubmed: 24631273
Respir Med Case Rep. 2016 Jan 15;17:44-6
pubmed: 27222784
Nat Genet. 2007 Apr;39(4):429-30
pubmed: 17392797
Sarcoidosis Vasc Diffuse Lung Dis. 2016 Jan 18;32(4):360-7
pubmed: 26847104
Autoimmun Rev. 2017 Feb;16(2):168-172
pubmed: 27988433
Chest. 1994 Aug;106(2):490-5
pubmed: 7774325
Lancet. 2015 Apr 11;385(9976):1460-71
pubmed: 25481618
J Allergy Clin Immunol. 2007 Oct;120(4):795-7
pubmed: 17854877
Proc Am Thorac Soc. 2005;2(5):417-21
pubmed: 16322592
J Allergy Clin Immunol. 2014 Feb;133(2):535-42
pubmed: 24131823
Medicine (Baltimore). 2000 Mar;79(2):69-79
pubmed: 10771705
Clin Immunol. 2010 Oct;137(1):21-30
pubmed: 20675197
Arthritis Rheumatol. 2015 Sep;67(9):2466-75
pubmed: 25988916
Clin Immunol. 2012 Jul;144(1):24-5
pubmed: 22659031
J Clin Immunol. 2010 Jan;30(1):10-6
pubmed: 20101521
Respir Med. 2008 Feb;102(2):307-12
pubmed: 17997299
J Bras Pneumol. 2009 Oct;35(10):1008-17
pubmed: 19918634
Mayo Clin Proc. 1983 Oct;58(10):665-83
pubmed: 6353084
J Allergy Clin Immunol Pract. 2016 Nov - Dec;4(6):1039-1052
pubmed: 27836055
Front Immunol. 2018 Aug 08;9:1837
pubmed: 30147696
J Allergy Clin Immunol. 2015 Nov;136(5):1186-205.e1-78
pubmed: 26371839
Eur Respir J. 2001 Sep;18(3):571-88
pubmed: 11589357
Ann Allergy Asthma Immunol. 2005 May;94(5 Suppl 1):S1-63
pubmed: 15945566
Forensic Sci Int. 2016 May;262:e1-4
pubmed: 27017172
J Clin Immunol. 2013 Nov;33(8):1325-35
pubmed: 24122029
Chest. 1991 Aug;100(2):552-3
pubmed: 1864136
J Clin Immunol. 2001 Sep;21(5):303-9
pubmed: 11720003
Lancet. 1987 May 9;1(8541):1075-7
pubmed: 2883406
J Clin Immunol. 2013 Jan;33(1):84-95
pubmed: 22986767
Ann Rheum Dis. 2015 Jun;74(6):1171-7
pubmed: 25667206
Autoimmun Rev. 2012 May;11(6-7):A404-12
pubmed: 22178509
J Allergy Clin Immunol Pract. 2019 Jul - Aug;7(6):1763-1770
pubmed: 30776527
Eur Respir Rev. 2018 Aug 29;27(149):
pubmed: 30158276
Lancet Respir Med. 2015 Aug;3(8):651-60
pubmed: 26188881
Respir Res. 2018 Nov 12;19(1):219
pubmed: 30419907
J Allergy Clin Immunol. 2009 Dec;124(6):1161-78
pubmed: 20004777
J Allergy Clin Immunol. 2002 Jun;109(6):1001-4
pubmed: 12063531
Am J Clin Pathol. 2004 Feb;121(2):200-4
pubmed: 14983932
Respir Med. 2017 Nov;132:181-188
pubmed: 29229095
N Engl J Med. 2003 Aug 7;349(6):583-96
pubmed: 12904524
Eur Respir J. 1993 Nov;6(10):1569-71
pubmed: 8112453
Eur J Respir Dis Suppl. 1986;147:6-15
pubmed: 3533593
Respir Res. 2007 Aug 05;8:57
pubmed: 17683588
Eur Respir J. 2005 Mar;25(3):482-9
pubmed: 15738292
J Clin Immunol. 2013 Jan;33(1):30-9
pubmed: 22930256
J Investig Allergol Clin Immunol. 2017;27(4):213-224
pubmed: 28731410
Chest. 2003 Sep;124(3):969-77
pubmed: 12970025
J Huazhong Univ Sci Technolog Med Sci. 2010 Oct;30(5):599-603
pubmed: 21063841
Br J Haematol. 2009 Jun;145(6):709-27
pubmed: 19344423
Blood. 2012 Aug 30;120(9):1953-4
pubmed: 22936739
Hematology Am Soc Hematol Educ Program. 2012;2012:301-5
pubmed: 23233596
Immunol Allergy Clin North Am. 2020 Aug;40(3):437-459
pubmed: 32654691
Allergy Asthma Proc. 2006 Jan-Feb;27(1):53-8
pubmed: 16598993
J Clin Immunol. 2019 Jan;39(1):45-54
pubmed: 30547383