Bone without borders - Monetite-based calcium phosphate guides bone formation beyond the skeletal envelope.
Bone
Calcium phosphate
Calcium pyrophosphate
Electron microscopy
Monetite
Raman spectroscopy
Journal
Bioactive materials
ISSN: 2452-199X
Titre abrégé: Bioact Mater
Pays: China
ID NLM: 101685294
Informations de publication
Date de publication:
Jan 2023
Jan 2023
Historique:
received:
16
11
2021
revised:
02
03
2022
accepted:
07
03
2022
entrez:
20
4
2022
pubmed:
21
4
2022
medline:
21
4
2022
Statut:
epublish
Résumé
Calcium phosphates (CaP) represent an important class of osteoconductive and osteoinductive biomaterials. As proof-of-concept, we show how a multi-component CaP formulation (monetite, beta-tricalcium phosphate, and calcium pyrophosphate) guides osteogenesis beyond the physiological envelope. In a sheep model, hollow dome-shaped constructs were placed directly over the occipital bone. At 12 months, large amounts of bone (∼75%) occupy the hollow space with strong evidence of ongoing remodelling. Features of both compact bone (osteonal/osteon-like arrangements) and spongy bone (trabeculae separated by marrow cavities) reveal insights into function/need-driven microstructural adaptation. Pores within the CaP also contain both woven bone and vascularised lamellar bone. Osteoclasts actively contribute to CaP degradation/removal. Of the constituent phases, only calcium pyrophosphate persists within osseous (cutting cones) and non-osseous (macrophages) sites. From a translational perspective, this multi-component CaP opens up exciting new avenues for osteotomy-free and minimally-invasive repair of large bone defects and augmentation of the dental alveolar ridge.
Identifiants
pubmed: 35441115
doi: 10.1016/j.bioactmat.2022.03.012
pii: S2452-199X(22)00128-1
pmc: PMC9005875
doi:
Types de publication
Journal Article
Langues
eng
Pagination
103-114Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
PT is a shareholder of OssDsign AB. TE and HE serve as consultants with OssDsign AB, are shareholders of OssDsign AB, and have two patents (US20130066324A130 and US9220597B232) relevant to this work.
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