Hippo Signaling Pathway Activation during SARS-CoV-2 Infection Contributes to Host Antiviral Response.
Journal
bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187
Informations de publication
Date de publication:
08 Apr 2022
08 Apr 2022
Historique:
entrez:
20
4
2022
pubmed:
21
4
2022
medline:
21
4
2022
Statut:
epublish
Résumé
SARS-CoV-2, responsible for the COVID-19 pandemic, causes respiratory failure and damage to multiple organ systems. The emergence of viral variants poses a risk of vaccine failures and prolongation of the pandemic. However, our understanding of the molecular basis of SARS-CoV-2 infection and subsequent COVID-19 pathophysiology is limited. In this study, we have uncovered a critical role for the evolutionarily conserved Hippo signaling pathway in COVID-19 pathogenesis. Given the complexity of COVID-19 associated cell injury and immunopathogenesis processes, we investigated Hippo pathway dynamics in SARS-CoV-2 infection by utilizing COVID-19 lung samples, and human cell models based on pluripotent stem cell-derived cardiomyocytes (PSC-CMs) and human primary lung air-liquid interface (ALI) cultures. SARS-CoV-2 infection caused activation of the Hippo signaling pathway in COVID-19 lung and
Identifiants
pubmed: 35441167
doi: 10.1101/2022.04.07.487520
pmc: PMC9016637
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI145044
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY032149
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK132735
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI149504
Pays : United States
Organisme : NINR NIH HHS
ID : R21 NR010361
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA208303
Pays : United States
Commentaires et corrections
Type : UpdateIn
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