Estimating survival after salvage surgery for recurrent salivary gland cancers: Systematic review.

recurrent salivary cancer recurrent salivary tumors salivary cancer failure salvage surgery salvage surgery outcomes

Journal

Head & neck
ISSN: 1097-0347
Titre abrégé: Head Neck
Pays: United States
ID NLM: 8902541

Informations de publication

Date de publication:
08 2022
Historique:
revised: 28 03 2022
received: 07 09 2021
accepted: 04 04 2022
pubmed: 21 4 2022
medline: 7 7 2022
entrez: 20 4 2022
Statut: ppublish

Résumé

Recurrent salivary gland carcinomas (RSCs) are poorly characterized and their clinical features and treatment options have not yet been fully described. The goal of this study was to analyze the therapeutic strategies and oncological outcomes of RSC patients through a literature review analysis. This systematic review was performed according to the PRISMA statements. Inclusion criteria for the systematic review were based on the population, intervention, comparison, and outcomes according to (PICO) framework. Two thousand seven hundred and four records were selected and 1817 recurrences were studied. Three hundred and sixty-five patients underwent salvage surgery (20.1%) and their 5-year mortality rate, overall survival and disease-free survival were 35%, 70%, and 42%, respectively. RSCs are aggressive neoplasms with a high rate of distant metastases (28.9%). Salvage surgery can be considered in patients with limited local and/or regional recurrences, even in case of single distant relapse, appearing within the first 3 years of follow-up.

Identifiants

pubmed: 35441406
doi: 10.1002/hed.27062
pmc: PMC9545583
doi:

Types de publication

Journal Article Review Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1961-1975

Informations de copyright

© 2022 The Authors. Head & Neck published by Wiley Periodicals LLC.

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Auteurs

Giuditta Mannelli (G)

Department of Experimental and Clinical Medicine, University of Florence, Florence.

Lara V Comini (LV)

Head and Neck Oncology and Robotic Surgery, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.

Andrea Sacchetto (A)

Otorhinolaryngology-Head and Neck Surgery, Department of Surgery, Dentistry, Gynecology, and Pediatrics, University of Verona, University Hospital of Verona, Verona, Italy.

Roberto Santoro (R)

Department of Experimental and Clinical Medicine, University of Florence, Florence.

Giuseppe Spinelli (G)

Department of Maxillo Facial Surgery, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.

Pierluigi Bonomo (P)

Radiation Oncology, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.

Isacco Desideri (I)

Radiation Oncology, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.

Paolo Bossi (P)

Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, ASST (Azienda Socio Sanitaria Territoriale) Spedali Civili, Brescia, Italy.

Ester Orlandi (E)

Radiation Oncology, Clinical Department, National Center for Oncological Hadrontherapy (CNAO), Pavia, Italy.

Giammarco Alderotti (G)

Department of Statistics, Computer Science, Applications "G. Parenti" (DiSIA), University of Florence, Florence, Italy.

Alessandro Franchi (A)

Department of Translational Research, School of Medicine, University of Pisa, Pisa, Italy.

Annarita Palomba (A)

Unit of Histopathology and Molecular Diagnostics, Careggi University Hospital, Florence, Italy.

Albino Eccher (A)

Pathology Unit, Department of Pathology and Diagnostics, University Hospital of Verona, Verona, Italy.

Daniele Marchioni (D)

Otorhinolaryngology-Head and Neck Surgery, Department of Surgery, Dentistry, Gynecology, and Pediatrics, University of Verona, University Hospital of Verona, Verona, Italy.

Riccardo Nocini (R)

Otorhinolaryngology-Head and Neck Surgery, Department of Surgery, Dentistry, Gynecology, and Pediatrics, University of Verona, University Hospital of Verona, Verona, Italy.

Cesare Piazza (C)

Unit of Otorhinolaryngology-Head and Neck Surgery, ASST Spedali Civili of Brescia, University of Brescia, Brescia, Italy.

Gabriele Molteni (G)

Otorhinolaryngology-Head and Neck Surgery, Department of Surgery, Dentistry, Gynecology, and Pediatrics, University of Verona, University Hospital of Verona, Verona, Italy.

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