Metabolic Activation and Cytotoxicity of Propafenone Mediated by CYP2D6.

Acetylcysteine / metabolism Activation, Metabolic Animals Chemical and Drug Induced Liver Injury / metabolism Cytochrome P-450 CYP2D6 / metabolism Glutathione / metabolism Microsomes, Liver / metabolism Propafenone / metabolism Quinones / metabolism Rats

Journal

Chemical research in toxicology
ISSN: 1520-5010
Titre abrégé: Chem Res Toxicol
Pays: United States
ID NLM: 8807448

Informations de publication

Date de publication:
16 05 2022
Historique:
pubmed: 21 4 2022
medline: 18 5 2022
entrez: 20 4 2022
Statut: ppublish

Résumé

Propafenone (PPF) is a class I

Identifiants

DOI: 10.1021/acs.chemrestox.2c00013 PMID: 35442037
pubmed: 35442037
doi: 10.1021/acs.chemrestox.2c00013
doi:

Substances chimiques

Quinones 0
Propafenone 68IQX3T69U
Cytochrome P-450 CYP2D6 EC 1.14.14.1
Glutathione GAN16C9B8O
Acetylcysteine WYQ7N0BPYC

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

829-839

Auteurs

Jiaru Li (J)

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P. R. China.

Junzu Shi (J)

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P. R. China.

Chenyang Jia (C)

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P. R. China.

Wei Li (W)

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P. R. China.

Ying Peng (Y)

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P. R. China.

Jiang Zheng (J)

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P. R. China.
State Key Laboratory of Functions and Applications of Medicinal Plants, Key Laboratory of Pharmaceutics of Guizhou Province, Guizhou Medical University, Guiyang, Guizhou 550025, P. R. China.
Key Laboratory of Environmental Pollution, Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, Guizhou 550025, P. R. China.
ORCID: 0000-0002-8187-2147

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés soufrés › Cystéine › Acétylcystéine › Metabolic Activation and Cytotoxicity of...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Biotransformation › Activation métabolique › Metabolic Activation and Cytotoxicity of...
questionsmedicales.fr › Eucaryotes › Animaux › Metabolic Activation and Cytotoxicity of...
questionsmedicales.fr › Troubles dus à des produits chimiques › Intoxication › Lésions hépatiques dues aux substances › Metabolic Activation and Cytotoxicity of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › Famille-2 de cytochromes P450 › Cytochrome P-450 CYP2D6 › Metabolic Activation and Cytotoxicity of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Oligopeptides › Glutathion › Metabolic Activation and Cytotoxicity of...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Microsomes › Microsomes du foie › Metabolic Activation and Cytotoxicity of...
questionsmedicales.fr › Composés chimiques organiques › Cétones › Propiophénones › Propafénone › Metabolic Activation and Cytotoxicity of...
questionsmedicales.fr › Composés chimiques organiques › Quinones › Metabolic Activation and Cytotoxicity of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Metabolic Activation and Cytotoxicity of...