Comparison of Serum Uric Acid Levels Among Men and Women with Metabolic Syndrome - A Study.

This case sieries gives three different cases with three different presentation and different approaches to a patient with short stature. Metabolic syndrome (MetS) is a conglomeration of biochemical and clinical abnormalities. It is now being considered as a pandemic disease and an evolving cause of morbidity and mortality worldwide. Metabolic syndrome constitutes various parameters. Approximately every third adult in India suffers from MetS. Among these, people from urban areas, women and north-eastern regions of India have a higher prevalence. Recent studies have established a correlation between Metabolic Syndrome and Uric acid. Since the predictors of hyperuricemia, such as, centripetal obesity and elevated serum triglyceride levels overlap with the components of MetS, it is pertinent that the correlation between hyperuricemia and MetS be evaluated. The results of establishing a correlation between the two maybe implicated in treating hyperuricemia early and thereby preventing the development of cardiovascular disease and reducing the rising numbers of MetS associated mortality. This study shows comparison of Serum uric acid levels among men and women with metabolic syndrome and with its parameters. This is a cross-sectional study done over a period of 20 months at a tertiary care center in Mysore. 135 women and 135 men with MetS (according to NCEP ATP III 2005) were included into the study by purposive sampling method. Fasting blood sample, Blood pressure readings, anthropometric measurements and medical history of the patients in the study population were taken. This study showed that mean waist circumference (WC) in men, 93.2cm (±5.96cm) was significantly higher (p<0.001) than women, 90.07cm (±6.09cm).The study proves a positive association of increased SUA levels is with Increased WC. (p=0.004), however there was no statistical difference among women and men with MetS. This study represents that there is no positive association (p=0.6) between Serum Uric Acid levels and women with MetS. This research did not to establish correlation between hyperuricemia in women with MetS as shown by previous studies. However, it can be concluded that increased SUA levels is associated with Increased WC. It was also observed that men with MetS have increased WC (Abdominal Obesity) than women with MetS.

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© Journal of the Association of Physicians of India 2011.