A Study of Role of Ngal in Diagnosis and Staging the Severity of Diabetic Nephropathy in Type 2 Diabetes Mellitus Patients in Sms Medical College, Jaipur.

Present work was conducted to study of role of NGAL in diagnosis and staging the severity of diabetic nephropathy in type 2 diabetes mellitus patients to assess serum NGAL, urine albumin levels in diabetic patients with and without apparent nephropathy. Comparative study conducted in the General Medicine department of SMS Hospital. Patients of type 2 Diabetes mellitus. Patients consuming high protein diet, pregnancy, severe muscular exercises, orthostatic albuminuria, congestive heart failure, urinary tract infections, liver diseases. Patients with type 1 diabetes mellitus. The mean age of patient was 51.7 years. Here, HbA1c and NGAL were negatively correlated with each other with Pearson correlation -0.484 (p-value<0.05). In prediabetic patients mean NGAL was 407ng/ml and as HbA1c increases mean NGAL decreases 276.69 ng/ml (P-value <0.0012). As ACR increases mean NGAL increases significantly (P-value<0.05). Neutrophil gelatinase-associated lipocalin could be a renal function evaluation marker for patients with renal dysfunction and markers for detection of diabetic nephropathy in patients with type2 diabetes mellitus.

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© Journal of the Association of Physicians of India 2011.