Exploring the conformational diversity of proteins.

Artificial Intelligence Membrane Transport Proteins Molecular Conformation Molecular Dynamics Simulation
G-protein coupled receptors artificial intelligence conformational dynamics machine learning molecular biophysics none protein structure prediction structural biology transmembrane protein transporters

Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
21 04 2022
Historique:
entrez: 21 4 2022
pubmed: 22 4 2022
medline: 23 4 2022
Statut: epublish

Résumé

An artificial intelligence-based method can predict distinct conformational states of membrane transporters and receptors.

Identifiants

DOI: 10.7554/eLife.78549 PMID: 35443909 PMC: PMC9023052
pubmed: 35443909
doi: 10.7554/eLife.78549
pii: 78549
pmc: PMC9023052
doi:
pii:

Substances chimiques

Membrane Transport Proteins 0

Types de publication

Editorial

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2022, Schlessinger and Bonomi.

Déclaration de conflit d'intérêts

AS, MB No competing interests declared

Références

Nature. 2021 Aug;596(7873):590-596
pubmed: 34293799
Proc Natl Acad Sci U S A. 2021 Sep 14;118(37):
pubmed: 34507995
Nature. 2021 Aug;596(7873):583-589
pubmed: 34265844
Acta Crystallogr D Struct Biol. 2022 Jan 1;78(Pt 1):1-13
pubmed: 34981757
Nat Commun. 2019 Jul 31;10(1):3427
pubmed: 31366933
Elife. 2022 Mar 03;11:
pubmed: 35238773
Science. 2001 Oct 5;294(5540):93-6
pubmed: 11588250

Auteurs

Avner Schlessinger (A)

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, United States.
ORCID: 0000-0003-4007-7814

Massimiliano Bonomi (M)

Department of Structural Biology and Chemistry, Institut Pasteur, Université Paris Cité, Paris, France.
ORCID: 0000-0002-7321-0004

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Algorithmes › Intelligence artificielle › Exploring the conformational diversity of proteins.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Exploring the conformational diversity of proteins.
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Exploring the conformational diversity of proteins.
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de dynamique moléculaire › Exploring the conformational diversity of proteins.