The Quality of Life of People with Solid Cancer is Less Worse than Other Diseases with better Prognosis, Except in the Presence of Depression.
Depression
Health-related quality of life
Oncology
Psychiatric comorbidity
Psycho-oncology
Psychosocial health
Journal
Clinical practice and epidemiology in mental health : CP & EMH
ISSN: 1745-0179
Titre abrégé: Clin Pract Epidemiol Ment Health
Pays: United Arab Emirates
ID NLM: 101245735
Informations de publication
Date de publication:
2021
2021
Historique:
received:
19
12
2020
revised:
08
07
2021
accepted:
09
07
2021
entrez:
21
4
2022
pubmed:
22
4
2022
medline:
22
4
2022
Statut:
epublish
Résumé
Suffering from Solid Cancer (SC) may adversely impact the Health-related Quality of Life (H-QoL). The aims of this study are to measure the H-QoL in a sample of people suffering from SC and to clarify the role of the co-occurrence of depressive episodes. Results were compared with a healthy control group and with groups of other disorders. In 151 patients with SC (mean±sd age 63.1±11.5; female 54.3%), H-QoL was assessed by SF-12, depressive episodes were identified by PHQ-9. The attributable burden of SC in impairing H-QoL was calculated as the difference between SF-12 score of a community sex and age ¼ matched healthy control group and that of the study sample. The attributable burden of SC was compared with other chronic diseases using specific diagnostic groups drawn from case-control studies that used the same database for selecting control samples. H-QoL in people with SC was significantly worse than in the healthy control group (p<0.0001). The attributable burden in worsening the H-QoL due to SC was similar to those of severe chronic diseases, but lower than Multiple Sclerosis (p<0.0001) or Fibromyalgia (p<0.00001). Having a depressive episode was a strong determinant of decreasing H-QoL, regardless of the severity of cancer. The findings confirm a strong impact of SC but showed that H-QoL in SC was higher than in chronic diseases with better "quoad vitam" outcome. Since depression was a strong determinant, its prevention, early detection and therapy are the main objectives that must be reached in cancer patients.
Sections du résumé
Background
UNASSIGNED
Suffering from Solid Cancer (SC) may adversely impact the Health-related Quality of Life (H-QoL). The aims of this study are to measure the H-QoL in a sample of people suffering from SC and to clarify the role of the co-occurrence of depressive episodes. Results were compared with a healthy control group and with groups of other disorders.
Methods
UNASSIGNED
In 151 patients with SC (mean±sd age 63.1±11.5; female 54.3%), H-QoL was assessed by SF-12, depressive episodes were identified by PHQ-9. The attributable burden of SC in impairing H-QoL was calculated as the difference between SF-12 score of a community sex and age ¼ matched healthy control group and that of the study sample. The attributable burden of SC was compared with other chronic diseases using specific diagnostic groups drawn from case-control studies that used the same database for selecting control samples.
Results
UNASSIGNED
H-QoL in people with SC was significantly worse than in the healthy control group (p<0.0001). The attributable burden in worsening the H-QoL due to SC was similar to those of severe chronic diseases, but lower than Multiple Sclerosis (p<0.0001) or Fibromyalgia (p<0.00001). Having a depressive episode was a strong determinant of decreasing H-QoL, regardless of the severity of cancer.
Conclusion
UNASSIGNED
The findings confirm a strong impact of SC but showed that H-QoL in SC was higher than in chronic diseases with better "quoad vitam" outcome. Since depression was a strong determinant, its prevention, early detection and therapy are the main objectives that must be reached in cancer patients.
Identifiants
pubmed: 35444707
doi: 10.2174/1745017902117010315
pii: CPEMH-17-315
pmc: PMC8985466
doi:
Types de publication
Journal Article
Langues
eng
Pagination
315-323Informations de copyright
© 2021 Aviles Gonzalez et al.
Références
Int J Geriatr Psychiatry. 2020 Oct;35(10):1189-1197
pubmed: 32497391
J Affect Disord. 2012 Dec 10;141(2-3):343-51
pubmed: 22727334
Int Rev Psychiatry. 2017 Oct;29(5):473-488
pubmed: 28681628
Clin Pract Epidemiol Ment Health. 2018 Jan 31;14:1-5
pubmed: 29492097
JCO Clin Cancer Inform. 2019 Sep;3:1-8
pubmed: 31545654
Neurology. 2021 Jan 26;96(4):e501-e512
pubmed: 33239364
Expert Rev Hematol. 2009 Feb;2(1):69-80
pubmed: 21082996
Support Care Cancer. 2012 Oct;20(10):2545-52
pubmed: 22262132
Clin Pract Epidemiol Ment Health. 2020 Jul 30;16:174-179
pubmed: 32874192
Psychooncology. 2007 Jul;16(7):644-50
pubmed: 17094162
Front Psychol. 2020 Sep 24;11:542444
pubmed: 33101117
Eur J Cancer. 2009 Jan;45(2):228-47
pubmed: 19097774
BMC Health Serv Res. 2009 Oct 21;9:190
pubmed: 19845942
Med Care. 1996 Mar;34(3):220-33
pubmed: 8628042
Biol Blood Marrow Transplant. 2011 Jun;17(6):861-6
pubmed: 20870029
Support Care Cancer. 2018 Feb;26(2):651-656
pubmed: 28918552
Support Care Cancer. 2020 Oct;28(10):4589-4612
pubmed: 32533435
World Neurosurg. 2020 Oct;142:e458-e473
pubmed: 32682998
Clin Pract Epidemiol Ment Health. 2018 Mar 21;14:63-69
pubmed: 29643929
Clin Pract Epidemiol Ment Health. 2019 Feb 20;15:30-37
pubmed: 30972140
Int J Soc Psychiatry. 2018 Nov;64(7):647-655
pubmed: 30146928
Lancet. 2016 Mar 12;387(10023):1094-1108
pubmed: 26354523
Front Psychol. 2019 Mar 12;10:480
pubmed: 30914997
Cancers (Basel). 2019 Apr 10;11(4):
pubmed: 30974857
JAMA. 1999 Nov 10;282(18):1737-44
pubmed: 10568646
BMC Psychiatry. 2012 May 30;12:52
pubmed: 22646910
J Affect Disord. 2012 Feb;136(3):775-80
pubmed: 22030133
J Natl Cancer Inst. 2014 Sep 29;106(9):
pubmed: 25265940
BMJ Open. 2018 Dec 6;8(12):e022711
pubmed: 30530472
Ann Behav Med. 2012 Jun;43(3):402-8
pubmed: 22167580
BMC Cancer. 2019 Jun 11;19(1):566
pubmed: 31185949
Br J Gen Pract. 2007 Aug;57(541):650-2
pubmed: 17688760
Clin Pract Epidemiol Ment Health. 2012;8:169-74
pubmed: 23248678
Pain Med. 2020 May 1;21(5):882-888
pubmed: 31986200
BMJ Open. 2017 Nov 28;7(11):e015860
pubmed: 29187408
Soc Sci Med. 1995 Nov;41(10):1403-9
pubmed: 8560308
Semin Arthritis Rheum. 2020 Dec;50(6):1457-1464
pubmed: 32173059
Qual Life Res. 2020 Feb;29(2):483-494
pubmed: 31707694
Ann Palliat Med. 2019 Apr;8(2):104-111
pubmed: 29156896
Neuropsychopharmacology. 2021 Mar;46(4):809-819
pubmed: 33230268
Support Care Cancer. 1996 Mar;4(2):129-40
pubmed: 8673350
J Pain Symptom Manage. 1994 Apr;9(3):186-92
pubmed: 8014530
Front Psychiatry. 2020 Mar 31;11:188
pubmed: 32296351
Eur J Cancer. 2002 Jul;38(10):1351-7
pubmed: 12091066
BMC Psychiatry. 2015 Nov 12;15:277
pubmed: 26563766
Br J Nutr. 2002 Dec;88 Suppl 3:S273-9
pubmed: 12498627
Psychooncology. 2019 Feb;28(2):271-277
pubmed: 30380589
Clin Pract Epidemiol Ment Health. 2019 Feb 28;15:38-43
pubmed: 30972141
Health Qual Life Outcomes. 2016 May 20;14:80
pubmed: 27206557
Bone Marrow Transplant. 2006 Jan;37(2):165-9
pubmed: 16299541
J Behav Med. 2013 Dec;36(6):591-600
pubmed: 22926317
Clin Pract Epidemiol Ment Health. 2015 Dec 31;11:180-5
pubmed: 26962323
Mol Oncol. 2021 Mar;15(3):779-789
pubmed: 33021030
Clin Pract Epidemiol Ment Health. 2010 Aug 27;6:94-100
pubmed: 21253459
Lancet. 2017 Mar 18;389(10074):1134-1150
pubmed: 27865536
Cancer. 2004 Jan 15;100(2):425-32
pubmed: 14716781
Psychol Med. 2000 Jul;30(4):831-40
pubmed: 11037091
J Affect Disord. 2014;167:192-7
pubmed: 24995886