Direct Ink Writing of Biocompatible Nanocellulose and Chitosan Hydrogels for Implant Mesh Matrices.
Journal
ACS polymers Au
ISSN: 2694-2453
Titre abrégé: ACS Polym Au
Pays: United States
ID NLM: 9918248914506676
Informations de publication
Date de publication:
13 Apr 2022
13 Apr 2022
Historique:
received:
14
10
2021
revised:
23
11
2021
accepted:
29
11
2021
entrez:
21
4
2022
pubmed:
22
4
2022
medline:
22
4
2022
Statut:
ppublish
Résumé
Direct ink writing via single or multihead extrusion is used to synthesize layer-by-layer (LbL) meshes comprising renewable polysaccharides. The best mechanical performance (683 ± 63 MPa modulus and 2.5 ± 0.4 MPa tensile strength) is observed for 3D printed structures with full infill density, given the role of electrostatic complexation between the oppositely charged components (chitosan and cellulose nanofibrils). The LbL structures develop an unexpectedly high wet stability that undergoes gradual weight loss at neutral and slightly acidic pH. The excellent biocompatibility and noncytotoxicity toward human monocyte/macrophages and controllable shrinkage upon solvent exchange make the cellular meshes appropriate for use as biomedical implants.
Identifiants
pubmed: 35445214
doi: 10.1021/acspolymersau.1c00045
pmc: PMC9011395
doi:
Types de publication
Journal Article
Langues
eng
Pagination
97-107Informations de copyright
© 2021 The Authors. Published by American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
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