Biolabel-led research pattern reveals serum profile in rats after treatment with Herba Lysimachiae: Combined analysis of metabonomics and proteomics.
Herba Lysimachiae
metabonomics
proteomics
serum profile
Journal
Biomedical chromatography : BMC
ISSN: 1099-0801
Titre abrégé: Biomed Chromatogr
Pays: England
ID NLM: 8610241
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
revised:
08
04
2022
received:
18
02
2022
accepted:
18
04
2022
pubmed:
22
4
2022
medline:
16
6
2022
entrez:
21
4
2022
Statut:
ppublish
Résumé
In traditional Chinese medicine, Herba Lysimachiae (HL) is mainly used to treat rheumatic arthralgia. Current pharmacological studies also showed that HL has therapeutic potential for synovial diseases. HL is an oral drug, whose compounds need to enter the blood circulation before reaching the injured tissue, thus potentially causing activity or toxicity to the blood system. In this study, the biolabel-led research pattern was used to analyze the serum profile after HL intervention, based on which the safety and efficacy of HL were explored. Metabonomics and proteomics were combined to analyze the biolabels responsible for the interventions of HL in serum. Bioinformatics databases were used to screen for the material basis that may interfere with biolabels. Omics analysis showed that differentially expressed proteins (19) and metabolites (5) were identified and considered as the potential biolabels, which were involved in 8 biochemical processes (platelet activation and aggregation, blood glucose release, immune and inflammatory regulation, oxidative stress, endoplasmic reticulum stress, tumor progression, blood pressure regulation, and uric acid synthesis). Thirty-one compounds may be the material basis to interfere with 11 biolabels. The present research reveals that the potential activities and toxicities of HL can be explored based on the biolabel-led research pattern.
Substances chimiques
Drugs, Chinese Herbal
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e5385Subventions
Organisme : National Key R&D programs of China
ID : 2018YFC1708100
Organisme : National Natural Science Foundation of China
ID : 81760784
Organisme : High-level Talents Project of Guizhou Province
ID : GUTCM[ZQ2018003]
Organisme : Research Center of Pharmacodynamic Material Basis and Mechanism of Guizhou University of Traditional Chinese Medicine
ID : (2019)70
Informations de copyright
© 2022 John Wiley & Sons Ltd.
Références
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