Handgrip strength and all-cause dementia incidence and mortality: findings from the UK Biobank prospective cohort study.
Adults
Alzheimer
Mortality
Muscular strength
Prevention
Vascular dementia
Journal
Journal of cachexia, sarcopenia and muscle
ISSN: 2190-6009
Titre abrégé: J Cachexia Sarcopenia Muscle
Pays: Germany
ID NLM: 101552883
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
revised:
28
09
2021
received:
27
10
2020
accepted:
11
10
2021
pubmed:
22
4
2022
medline:
11
6
2022
entrez:
21
4
2022
Statut:
ppublish
Résumé
This study aimed to investigate the associations of grip strength with incidence and mortality from dementia and whether these associations differ by sociodemographic and lifestyle factors. A total of 466 788 participants of the UK Biobank (median age 56.5 years, 54.5% women). The outcome was all-cause dementia incidence and mortality and the exposure was grip strength. Grip strength was assessed using a Jamar J00105 hydraulic hand dynamometer. Excluding the first 2 years of follow-up (landmark analysis), mean follow-up was 9.1 years (inter-quartile range: 8.3; 9.7) for incidence and 9.3 (inter-quartile range: 8.7; 10.0) for mortality. During this time, 4087 participants developed dementia, and 1309 died from it. Lower grip strength was associated with a higher risk of dementia incidence and mortality independent of major confounding factors (P < 0.001). Individuals in the lowest quintile of grip strength had 72% [95% confidence interval (CI): 1.55; 1.92] higher incident dementia risk and 87% [95% CI: 1.55; 2.26] higher risk of dementia mortality compared with those in the highest quintile. Our PAF analyses indicate that 30.1% of dementia cases and 32.3% of dementia deaths are attributable to having low grip strength. The association between grip strength and dementia outcomes did not differ by lifestyle or sociodemographic factors. Lower grip strength was associated with a higher risk of all-cause dementia incidence and mortality, independently of important confounding factors.
Sections du résumé
BACKGROUND
This study aimed to investigate the associations of grip strength with incidence and mortality from dementia and whether these associations differ by sociodemographic and lifestyle factors.
METHODS
A total of 466 788 participants of the UK Biobank (median age 56.5 years, 54.5% women). The outcome was all-cause dementia incidence and mortality and the exposure was grip strength. Grip strength was assessed using a Jamar J00105 hydraulic hand dynamometer.
RESULTS
Excluding the first 2 years of follow-up (landmark analysis), mean follow-up was 9.1 years (inter-quartile range: 8.3; 9.7) for incidence and 9.3 (inter-quartile range: 8.7; 10.0) for mortality. During this time, 4087 participants developed dementia, and 1309 died from it. Lower grip strength was associated with a higher risk of dementia incidence and mortality independent of major confounding factors (P < 0.001). Individuals in the lowest quintile of grip strength had 72% [95% confidence interval (CI): 1.55; 1.92] higher incident dementia risk and 87% [95% CI: 1.55; 2.26] higher risk of dementia mortality compared with those in the highest quintile. Our PAF analyses indicate that 30.1% of dementia cases and 32.3% of dementia deaths are attributable to having low grip strength. The association between grip strength and dementia outcomes did not differ by lifestyle or sociodemographic factors.
CONCLUSIONS
Lower grip strength was associated with a higher risk of all-cause dementia incidence and mortality, independently of important confounding factors.
Identifiants
pubmed: 35445560
doi: 10.1002/jcsm.12857
pmc: PMC9178163
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1514-1525Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Department of Health [UK]
Organisme : Spanish Ministry of Science and Innovation
Organisme : British Heart Foundation
Pays : United Kingdom
Organisme : Welsh assembly government
Organisme : University of Granada
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Organisme : Spanish Ministry of Economy and Competitiveness
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Informations de copyright
© 2022 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders.
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