Recent insights into the structure and function of coronavirus ribonucleases.
SARS-CoV-2
coronaviruses
drug design
endonucleases
exonucleases
structural biology
Journal
FEBS open bio
ISSN: 2211-5463
Titre abrégé: FEBS Open Bio
Pays: England
ID NLM: 101580716
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
revised:
07
04
2022
received:
08
03
2022
accepted:
19
04
2022
pubmed:
22
4
2022
medline:
9
9
2022
entrez:
21
4
2022
Statut:
ppublish
Résumé
Coronaviruses use approximately two-thirds of their 30-kb genomes to encode nonstructural proteins (nsps) with diverse functions that assist in viral replication and transcription, and evasion of the host immune response. The SARS-CoV-2 pandemic has led to renewed interest in the molecular mechanisms used by coronaviruses to infect cells and replicate. Among the 16 Nsps involved in replication and transcription, coronaviruses encode two ribonucleases that process the viral RNA-an exonuclease (Nsp14) and an endonuclease (Nsp15). In this review, we discuss recent structural and biochemical studies of these nucleases and the implications for drug discovery.
Identifiants
pubmed: 35445579
doi: 10.1002/2211-5463.13414
pmc: PMC9110870
doi:
Substances chimiques
Viral Nonstructural Proteins
0
Ribonucleases
EC 3.1.-
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1567-1583Informations de copyright
© 2022 The Authors. FEBS Open Bio published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.
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