A randomised controlled trial of non-invasive ventilation compared with extracorporeal carbon dioxide removal for acute hypercapnic exacerbations of chronic obstructive pulmonary disease.

AECOPD Acute exacerbations of chronic obstructive pulmonary disease ECCO2R Extracorporeal CO2 removal NIV Non-invasive ventilation

Journal

Annals of intensive care
ISSN: 2110-5820
Titre abrégé: Ann Intensive Care
Pays: Germany
ID NLM: 101562873

Informations de publication

Date de publication:
21 Apr 2022
Historique:
received: 29 11 2021
accepted: 22 03 2022
entrez: 21 4 2022
pubmed: 22 4 2022
medline: 22 4 2022
Statut: epublish

Résumé

Patients presenting with acute hypercapnic respiratory failure due to exacerbations of chronic obstructive pulmonary disease (AECOPD) are typically managed with non-invasive ventilation (NIV). The impact of low-flow extracorporeal carbon dioxide removal (ECCO Open-label randomised trial comparing NIV (NIV arm) with ECCO Eighteen patients (median age 67.5, IQR (61.5-71) years; median GOLD stage 3 were enrolled (nine in each arm). Time to NIV discontinuation was shorter with ECCO There is evidence of benefit associated with ECCO

Sections du résumé

BACKGROUND BACKGROUND
Patients presenting with acute hypercapnic respiratory failure due to exacerbations of chronic obstructive pulmonary disease (AECOPD) are typically managed with non-invasive ventilation (NIV). The impact of low-flow extracorporeal carbon dioxide removal (ECCO
METHODS METHODS
Open-label randomised trial comparing NIV (NIV arm) with ECCO
RESULTS RESULTS
Eighteen patients (median age 67.5, IQR (61.5-71) years; median GOLD stage 3 were enrolled (nine in each arm). Time to NIV discontinuation was shorter with ECCO
INTERPRETATION CONCLUSIONS
There is evidence of benefit associated with ECCO

Identifiants

DOI: 10.1186/s13613-022-01006-8 PMID: 35445986 PMC: PMC9021560
pubmed: 35445986
doi: 10.1186/s13613-022-01006-8
pii: 10.1186/s13613-022-01006-8
pmc: PMC9021560
doi:

Banques de données

ClinicalTrials.gov
['NCT02086084']

Types de publication

Journal Article

Langues

eng

Pagination

36

Informations de copyright

© 2022. The Author(s).

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Auteurs

Nicholas A Barrett (NA)

Department of Critical Care, NHS Foundation Trust, Guy's and St ThomasWestminster Bridge Rd, London, SE1 7EH, UK. nicholas.barrett@gstt.nhs.uk.
Centre for Human & Applied Physiological Sciences (CHAPS), School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, WC2R 2LS, UK. nicholas.barrett@gstt.nhs.uk.
ORCID: 0000-0002-4641-8192

Nicholas Hart (N)

Centre for Human & Applied Physiological Sciences (CHAPS), School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, WC2R 2LS, UK.
Lane Fox Respiratory Unit, Guy's and St. Thomas' NHS Foundation Trust, Westminster Bridge Rd, London, SE1 7EH, UK.

Kathleen J R Daly (KJR)

Department of Critical Care, NHS Foundation Trust, Guy's and St ThomasWestminster Bridge Rd, London, SE1 7EH, UK.

Martina Marotti (M)

Department of Critical Care, NHS Foundation Trust, Guy's and St ThomasWestminster Bridge Rd, London, SE1 7EH, UK.

Eirini Kostakou (E)

Department of Critical Care, NHS Foundation Trust, Guy's and St ThomasWestminster Bridge Rd, London, SE1 7EH, UK.

Chris Carlin (C)

Dept. of Respiratory Medicine, Queen Elizabeth University Hospital, Glasgow, G51 4TF, UK.

Stephanie Lua (S)

Dept. of Respiratory Medicine, Queen Elizabeth University Hospital, Glasgow, G51 4TF, UK.

Suveer Singh (S)

Department of Respiratory and Critical Care Medicine, Chelsea & Westminster Hospital, London, SW10 9NH, UK.

Andrew Bentley (A)

Department of Intensive Care & Respiratory Medicine, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, M23 9LT, UK.

Abdel Douiri (A)

School of Population Health & Environmental Sciences, King's College London, London, WC2R 2LS, UK.
National Institute for Health Research Biomedical Research Centre, Guy's and St. Thomas' NHS Trust and King's College London, London, WC2R 2LS, UK.

Luigi Camporota (L)

Department of Critical Care, NHS Foundation Trust, Guy's and St ThomasWestminster Bridge Rd, London, SE1 7EH, UK.
Centre for Human & Applied Physiological Sciences (CHAPS), School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, WC2R 2LS, UK.

Classifications MeSH