Conservation and Enhanced Binding of SARS-CoV-2 Omicron Spike Protein to Coreceptor Neuropilin-1 Predicted by Docking Analysis.
COVID-19
CendR
Omicron
SARS-CoV-2
neuropilin-1
spike protein
Journal
Infectious disease reports
ISSN: 2036-7430
Titre abrégé: Infect Dis Rep
Pays: Switzerland
ID NLM: 101537203
Informations de publication
Date de publication:
29 Mar 2022
29 Mar 2022
Historique:
received:
24
02
2022
revised:
22
03
2022
accepted:
25
03
2022
entrez:
21
4
2022
pubmed:
22
4
2022
medline:
22
4
2022
Statut:
epublish
Résumé
The Omicron variant of SARS-CoV-2 bears peptide sequence alterations that correlate with a higher infectivity than was observed in the original SARS-CoV-2 isolated from Wuhan, China. We analyzed the CendR motif of spike protein and performed in silico molecular docking with neuropilin-1 (Nrp1), a receptor-ligand interaction known to support infection by the original variant. Our analysis predicts conserved and slightly increased energetic favorability of binding for Omicron CendR:Nrp1. We propose that the viral spike:Nrp1 coreceptor pathway may contribute to the infectivity of the Omicron variant of SARS-CoV-2.
Identifiants
pubmed: 35447881
pii: idr14020029
doi: 10.3390/idr14020029
pmc: PMC9024780
doi:
Types de publication
Journal Article
Langues
eng
Pagination
243-249Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM103841
Pays : United States
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