Liver and White/Brown Fat Dystrophy Associates with Gut Microbiota and Metabolomic Alterations in 3xTg Alzheimer's Disease Mouse Model.
Alzheimer’s disease mouse model
PET-CT imaging
adipose tissues
gut microbiota
liver inflammation
metabolome
Journal
Metabolites
ISSN: 2218-1989
Titre abrégé: Metabolites
Pays: Switzerland
ID NLM: 101578790
Informations de publication
Date de publication:
22 Mar 2022
22 Mar 2022
Historique:
received:
03
03
2022
revised:
16
03
2022
accepted:
18
03
2022
entrez:
21
4
2022
pubmed:
22
4
2022
medline:
22
4
2022
Statut:
epublish
Résumé
Metabolic impairments and liver and adipose depots alterations were reported in subjects with Alzheimer's disease (AD), highlighting the role of the liver-adipose-tissue-brain axis in AD pathophysiology. The gut microbiota might play a modulating role. We investigated the alterations to the liver and white/brown adipose tissues (W/BAT) and their relationships with serum and gut metabolites and gut bacteria in a 3xTg mouse model during AD onset (adulthood) and progression (aging) and the impact of high-fat diet (HFD) and intranasal insulin (INI). Glucose metabolism (
Identifiants
pubmed: 35448465
pii: metabo12040278
doi: 10.3390/metabo12040278
pmc: PMC9028874
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Italian Ministry of Agricultural, Food and Forestry Policies
ID : Ministry Decree 23092/7303/19
Organisme : Italian Ministry of Education, University and Research
ID : Ministry Decree no. 946/2019
Organisme : Ministry of Science and Innovation of Spain
ID : ACPIN2017-117
Organisme : Ministry of Science and Innovation of Spain
ID : PID2019-108973RB-C22
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