Restricting Branched-Chain Amino Acids within a High-Fat Diet Prevents Obesity.
branched-chain amino acids
meta-analysis
metabolomics
obesity
phenylalanine
tryptophan
Journal
Metabolites
ISSN: 2218-1989
Titre abrégé: Metabolites
Pays: Switzerland
ID NLM: 101578790
Informations de publication
Date de publication:
07 Apr 2022
07 Apr 2022
Historique:
received:
18
03
2022
revised:
01
04
2022
accepted:
04
04
2022
entrez:
21
4
2022
pubmed:
22
4
2022
medline:
22
4
2022
Statut:
epublish
Résumé
Obesity is a global pandemic, but there is yet no effective measure to control it. Recent metabolomics studies have identified a signature of altered amino acid profiles to be associated with obesity, but it is unclear whether these findings have actionable clinical potential. The aims of this study were to reveal the metabolic alterations of obesity and to explore potential strategies to mitigate obesity. We performed targeted metabolomic profiling of the plasma/serum samples collected from six independent cohorts and conducted an individual data meta-analysis of metabolomics for body mass index (BMI) and obesity. Based on the findings, we hypothesized that restriction of branched-chain amino acids (BCAAs), phenylalanine, or tryptophan may prevent obesity and tested our hypothesis in a dietary restriction trial with eight groups of 4-week-old male C57BL/6J mice (n = 5/group) on eight different types of diets, respectively, for 16 weeks. A total of 3397 individuals were included in the meta-analysis. The mean BMI was 30.7 ± 6.1 kg/m
Identifiants
pubmed: 35448521
pii: metabo12040334
doi: 10.3390/metabo12040334
pmc: PMC9030079
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIA NIH HHS
ID : U01 AG18820; U01 AG18947; U01 AG19069; U01 AG18832
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG018947
Pays : United States
Organisme : CIHR
ID : FRN#175015; 153298; 143058; 132178; 156116; MOP192552;
Pays : Canada
Organisme : NIAMS NIH HHS
ID : P30 AR072571
Pays : United States
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