16S rRNA Gene Sequencing Revealed Changes in Gut Microbiota Composition during Pregnancy and Lactation in Mice Model.
gut microbiota
lactation
metabolites
pregnancy
reproductive hormones
Journal
Veterinary sciences
ISSN: 2306-7381
Titre abrégé: Vet Sci
Pays: Switzerland
ID NLM: 101680127
Informations de publication
Date de publication:
01 Apr 2022
01 Apr 2022
Historique:
received:
21
02
2022
revised:
29
03
2022
accepted:
30
03
2022
entrez:
21
4
2022
pubmed:
22
4
2022
medline:
22
4
2022
Statut:
epublish
Résumé
The gut microbiota play a vital role in regulating endocrine-mediated metabolism, immunity, and energy metabolism. However, little is known about the gut microbiota and metabolite composition and development throughout pregnancy and lactation. Here, we used amplicon sequencing to analyze the gut microbiota composition of 35 female mice in five stages of pregnancy and lactation, namely, non-receptive (NR) stages, sexually-receptive (SR) stages, at day 15 of pregnancy (Pre_D15), at the day of birth (Del), and at day 10 of lactation (Lac_D10). The results revealed that the α diversity of gut microbiota was significantly increased during pregnancy and lactation. In addition, the principal coordinate analysis (PCoA) conducted on the amplicon sequence variants' (ASVs') distribution of the 16S rRNA amplicons indicated that the microbiota composition was significantly different among the five groups. Based on a random forest analysis,
Identifiants
pubmed: 35448667
pii: vetsci9040169
doi: 10.3390/vetsci9040169
pmc: PMC9024687
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Tibet Academy of Agricultural and Animal Husbandry Sciences
ID : 2020WZ001 and XZ202001YD0017C
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