Age and body mass index affect fit of spirometry Global Lung Function Initiative references in schoolchildren.

Background

References from the Global Lung Function Initiative (GLI) are widely used to interpret children's spirometry results. We assessed fit for healthy schoolchildren.

Methods

LuftiBus in the School was a population-based cross-sectional study undertaken in 2013-2016 in the canton of Zurich, Switzerland. Parents and their children aged 6-17 years answered questionnaires about respiratory symptoms and lifestyle. Children underwent spirometry in a mobile lung function lab. We calculated GLI-based z-scores for forced expiratory volume in 1 s (FEV

Results

We analysed data from 2036 children with valid FEV

Conclusion

GLI-based FEV

Informations de copyright

Copyright ©The authors 2022.

Déclaration de conflit d'intérêts

Conflict of interest: A. Moeller reports receiving consulting fees from Vertex; payments or honoraria for lectures, presentations, speaker bureaus, manuscript writing or educational events received from Vertex and Vifor; participation on a data safety monitoring or advisory board for Vertex; and leadership or fiduciary roles in other boards, societies, committees or advocacy groups, paid or unpaid, held for ERS Assembly 7 (Secretary), SGP board, SGPP board, SWGCF (co-president) and SSSCS (vice-president). All disclosures made outside the submitted work. F. Singer reports support for the present manuscript received from the Bern Lung League foundation and Kinderinsel foundation; and payment or honoraria for lectures, presentations, speaker bureaus, manuscript writing or educational events received from Vertex and Novartis, outside the submitted work. P. Latzin reports receiving grants or contracts from Vertex and Vifor, outside the submitted work; payment or honoraria for lectures, presentations, speaker bureaus, manuscript writing or educational events received from Vertex, Vifor and OM Pharma, outside the submitted work; and participation on a data safety monitoring or advisory board for Polyphor, Santhera (DMC), Vertex, OM Pharma and Vifor, outside the submitted work. J. Usemann reports receiving grants or contracts from the Swiss Lung Foundation and Palatin Foundation, Basel, Switzerland, outside the submitted work; and payment or honoraria for lectures, presentations, speaker bureaus, manuscript writing or educational events received from Vertex, outside the submitted work. R. Mozun reports support for the present manuscript received from the Institute of Social and Preventive Medicine, University of Bern, at which she is employed. The remaining authors have nothing to disclose.