Hypoxia and Hypoxia-Inducible Factors in Lymphedema.
HIF
hypoxia
inflammation
lymphangiogensis
lymphedema
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2022
2022
Historique:
received:
08
01
2022
accepted:
14
03
2022
entrez:
22
4
2022
pubmed:
23
4
2022
medline:
23
4
2022
Statut:
epublish
Résumé
Lymphedema is a chronic inflammatory disorder characterized by edema, fat deposition, and fibrotic tissue remodeling. Despite significant advances in lymphatic biology research, our knowledge of lymphedema pathology is incomplete. Currently, there is no approved pharmacological therapy for this debilitating disease. Hypoxia is a recognized feature of inflammation, obesity, and fibrosis. Understanding hypoxia-regulated pathways in lymphedema may provide new insights into the pathobiology of this chronic disorder and help develop new medicinal treatments.
Identifiants
pubmed: 35450048
doi: 10.3389/fphar.2022.851057
pii: 851057
pmc: PMC9017680
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
851057Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL095686
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL141105
Pays : United States
Organisme : BLRD VA
ID : I01 BX005628
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL150583
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL158714
Pays : United States
Informations de copyright
Copyright © 2022 Jiang, Tian, Kim, McQuiston, Vinh, Rockson, Semenza and Nicolls.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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