Juvenile Xanthogranuloma as Differential Diagnosis of a Vulvar Mass: A Case Report.
juvenile xanthogranuloma
rhabdomyosarcoma
vulvar mass
Journal
European journal of pediatric surgery reports
ISSN: 2194-7619
Titre abrégé: European J Pediatr Surg Rep
Pays: Germany
ID NLM: 101620104
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
received:
04
07
2021
accepted:
23
11
2021
entrez:
22
4
2022
pubmed:
23
4
2022
medline:
23
4
2022
Statut:
epublish
Résumé
Vulvar masses in children are an unusual finding but their differential diagnosis is extensive. In case of solid masses, rhabdomyosarcoma (RMS) must always be considered due to the fact that it is the most common tumor in external genitals during childhood. However, RMS has a radiological appearance very similar to juvenile xanthogranuloma (JXG). We present a 16-month-old girl with a 2 cm solid mass on her left labia majora, with four overlying cutaneous papules. After imaging tests, an excisional biopsy was programmed due to high malignancy suspicion. Histopathology of the mass and one of the papules was diagnostic for JXG. After a 12-month follow-up, the patient shows no signs of relapse or complication. Deep JXG is an uncommon entity in childhood and exceptional in the genital area. Therefore, it must be included in the differential diagnosis of a solid vulvar mass, especially if accompanying yellowish xanthomatous cutaneous lesions are present.
Identifiants
pubmed: 35450098
doi: 10.1055/s-0042-1743159
pii: 210603cr
pmc: PMC9018129
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e25-e29Informations de copyright
The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( https://creativecommons.org/licenses/by/4.0/ ).
Déclaration de conflit d'intérêts
Conflict of Interest All of the authors declare no conflicts of interest.
Références
J Clin Diagn Res. 2016 Nov;10(11):ED21-ED22
pubmed: 28050386
Urology. 1981 Aug;18(2):189-90
pubmed: 6791346
Am J Surg Pathol. 2005 Jan;29(1):21-8
pubmed: 15613853
Pathologica. 2010 Apr;102(2):71-4
pubmed: 23596761
J Pediatr Adolesc Gynecol. 2000 May;13(2):75-8
pubmed: 10869967
J Urol. 1993 Aug;150(2 Pt 1):456-7
pubmed: 8326577
Klin Padiatr. 2005 Jul-Aug;217(4):238-9
pubmed: 16032551
J Pediatr Adolesc Gynecol. 2018 Jun;31(3):311-314
pubmed: 29305965
J Urol. 1983 Apr;129(4):841-2
pubmed: 6842718
Pol Tyg Lek. 1984 Jan 9;39(2):51-3
pubmed: 6429648
Pediatr Dermatol. 2008 Jan-Feb;25(1):97-8
pubmed: 18304165
Pediatr Dermatol. 2018 Sep;35(5):582-587
pubmed: 29999209
Am J Surg Pathol. 2004 Dec;28(12):1601-8
pubmed: 15577679
J Pediatr Urol. 2013 Aug;9(4):e144-6
pubmed: 23602842
Pediatr Radiol. 2009 Feb;39(2):176-9
pubmed: 19011852
J Urol. 1985 Jun;133(6):1054-5
pubmed: 3923211
J Low Genit Tract Dis. 2013 Jan;17(1):92-4
pubmed: 23222055
Zhonghua Bing Li Xue Za Zhi. 2010 Jan;39(1):40-3
pubmed: 20388398
Gynecol Oncol. 1994 Aug;54(2):254-8
pubmed: 8063257
Mod Pathol. 2011 Dec;24(12):1560-70
pubmed: 21822206
Ann Dermatol Venereol. 1997;124(2):167-70
pubmed: 9740830
Pathology. 2001 Nov;33(4):526-31
pubmed: 11827426
J Pediatr Surg. 2009 Oct;44(10):1920-3
pubmed: 19853747
J Pediatr Urol. 2013 Feb;9(1):e64-7
pubmed: 23103129
J Pediatr Adolesc Gynecol. 2016 Dec;29(6):e97-e99
pubmed: 27343432