Cerebrospinal Fluid Histamine Levels in Healthy Children and Potential Implication for SIDS: Observational Study in a French Tertiary Care Hospital.
SIDS
children
histamine
infant
maturation
sleep
Journal
Frontiers in pediatrics
ISSN: 2296-2360
Titre abrégé: Front Pediatr
Pays: Switzerland
ID NLM: 101615492
Informations de publication
Date de publication:
2022
2022
Historique:
received:
21
11
2021
accepted:
09
03
2022
entrez:
22
4
2022
pubmed:
23
4
2022
medline:
23
4
2022
Statut:
epublish
Résumé
A defect of the waking systems could constitute a factor of vulnerability for sudden infant death syndrome (SIDS). A decrease in orexin levels, which promotes wakefulness and activates histaminergic neurons (another hypothalamic wake-promoting system) has already been demonstrated between 2 and 6 months. This work aims to study the levels of histamine (HA), tele-methylhistamine (t-MeHA), its direct metabolite, and t-MeHA/HA ratio in the cerebrospinal fluid (CSF) of healthy children, to evaluate the maturation of the histaminergic system and its possible involvement in SIDS. Seventy Eight French children between 0 and 20 years (48.7% boys) were included, all of whom had a clinical indication for lumbar puncture, but subsequently found to be normal. Measurements of HA and t-MeHA in CSF were performed by reverse phase liquid chromatography coupled to mass spectrometry detection. Statistical analyses were performed using Spearman correlations and Non-parametric pairwise ranking tests. A negative correlation was found between age and CSF HA ( CSF HA and t-MeHA levels decrease with age in boys, and global levels are lower in boys than in girls. These results reveal changes in histaminergic transmission and metabolism during maturation. Whether lower CSF histamine values in boys compared to girls could contribute to their higher risk of SIDS warrants further research.
Identifiants
pubmed: 35450108
doi: 10.3389/fped.2022.819496
pmc: PMC9016218
doi:
Types de publication
Journal Article
Langues
eng
Pagination
819496Informations de copyright
Copyright © 2022 Plancoulaine, Guyon, Inocente, Germe, Zhang, Robert, Lin and Franco.
Déclaration de conflit d'intérêts
PF received funds for speaking and board engagements with UCB pharma and Biocodex. She is co-investigator in studies promoted by Bioprojet (Pitolisant) and Jazz (Sunosi). J-SL received funds for speaking and board engagements with Bioprojet. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Physiol Rev. 2008 Jul;88(3):1183-241
pubmed: 18626069
Lancet. 2007 Nov 3;370(9598):1578-87
pubmed: 17980736
Pflugers Arch. 2012 Jan;463(1):31-42
pubmed: 21796339
JAMA. 2006 Nov 1;296(17):2124-32
pubmed: 17077377
Cell Mol Neurobiol. 2014 Aug;34(6):777-89
pubmed: 24798513
Sleep. 2009 Feb;32(2):181-7
pubmed: 19238805
Sleep Med. 2017 May;33:125-129
pubmed: 28449891
J Neurosci. 1998 Dec 1;18(23):9996-10015
pubmed: 9822755
Neurosci Lett. 2001 Nov 9;313(3):125-8
pubmed: 11682143
Am J Epidemiol. 2006 Apr 15;163(8):762-9
pubmed: 16582034
Sleep Med. 2010 Aug;11(7):603-14
pubmed: 20630799
Sleep. 2009 Feb;32(2):175-80
pubmed: 19238804
Am J Respir Crit Care Med. 2003 Dec 1;168(11):1298-303
pubmed: 12917226
Neurobiol Dis. 2008 Apr;30(1):74-83
pubmed: 18295497
Br J Pharmacol. 2011 Jun;163(4):713-21
pubmed: 21615387
J Pharmacol Exp Ther. 2007 Jan;320(1):365-75
pubmed: 17005916
Arch Dis Child Fetal Neonatal Ed. 2002 Sep;87(2):F100-5
pubmed: 12193515
N Engl J Med. 2009 Aug 20;361(8):795-805
pubmed: 19692691
Exp Neurol. 2005 May;193(1):228-33
pubmed: 15817281
PLoS One. 2017 Sep 20;12(9):e0184958
pubmed: 28931039
Biol Neonate. 1994;65(3-4):194-7
pubmed: 8038282
J Neurosci. 2009 Nov 18;29(46):14423-38
pubmed: 19923277
BMJ. 1996 Jul 27;313(7051):191-5
pubmed: 8696193
Children (Basel). 2022 Feb 08;9(2):
pubmed: 35204943
Sleep Med. 2017 May;33:57-60
pubmed: 28449906
Sleep Med Rev. 2020 Jun;51:101276
pubmed: 32109833
Pharmacol Biochem Behav. 1994 Dec;49(4):997-1000
pubmed: 7886118
Sleep. 1992 Aug;15(4):287-92
pubmed: 1519001
Acta Neuropathol. 2015 Aug;130(2):185-98
pubmed: 25953524
Brain Res. 1973 Mar 30;52:323-32
pubmed: 4739806
J Neurosci. 2005 Jul 13;25(28):6716-20
pubmed: 16014733
Med Hypotheses. 2004;62(4):564-7
pubmed: 15050108
Nat Commun. 2021 Jan 19;12(1):447
pubmed: 33469018
Anal Biochem. 2011 Feb 1;409(1):28-36
pubmed: 20932951
Sleep Med. 2020 Feb;66:220-226
pubmed: 31978866
Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):7695-7700
pubmed: 28674018
Pediatrics. 1992 May;89(5 Pt 1):865-70
pubmed: 1579396
Sleep Med Rev. 2000 Oct;4(5):471-503
pubmed: 17210278
Sleep. 2012 Oct 01;35(10):1359-66
pubmed: 23024434
CNS Neurosci Ther. 2019 Mar;25(3):386-395
pubmed: 30225986