Stereochemical Effects on the Antimicrobial Properties of Tetrasubstituted 2,5-Diketopiperazines.


Journal

ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073

Informations de publication

Date de publication:
14 Apr 2022
Historique:
received: 13 12 2021
accepted: 31 03 2022
entrez: 22 4 2022
pubmed: 23 4 2022
medline: 23 4 2022
Statut: epublish

Résumé

Antimicrobial drug resistance is a looming health crisis facing us in the modern era, and new drugs are urgently needed to combat this growing problem. Synthetic mimics of antimicrobial peptides have recently emerged as a promising class of compounds for the treatment of persistent microbial infections. In the current study, we investigate five cyclic

Identifiants

pubmed: 35450374
doi: 10.1021/acsmedchemlett.1c00683
pmc: PMC9014430
doi:

Types de publication

Journal Article

Langues

eng

Pagination

632-640

Informations de copyright

© 2022 American Chemical Society.

Déclaration de conflit d'intérêts

The authors declare no competing financial interest.

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Auteurs

Thomas M Grant (TM)

School of Chemical Sciences, University of Auckland, 23 Symonds Street, Auckland 1142, New Zealand.

David Rennison (D)

School of Chemical Sciences, University of Auckland, 23 Symonds Street, Auckland 1142, New Zealand.

Alexandra L Krause (AL)

Department of Microbiology and Immunology, School of Biomedical Sciences, University of Otago, Dunedin 9016, New Zealand.

Sonya Mros (S)

Department of Microbiology and Immunology, School of Biomedical Sciences, University of Otago, Dunedin 9016, New Zealand.

Scott A Ferguson (SA)

Department of Microbiology and Immunology, School of Biomedical Sciences, University of Otago, Dunedin 9016, New Zealand.

Gregory M Cook (GM)

Department of Microbiology and Immunology, School of Biomedical Sciences, University of Otago, Dunedin 9016, New Zealand.
Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland 1142, New Zealand.

Alan Cameron (A)

School of Chemical Sciences, University of Auckland, 23 Symonds Street, Auckland 1142, New Zealand.

Homayon J Arabshahi (HJ)

School of Chemical Sciences, University of Auckland, 23 Symonds Street, Auckland 1142, New Zealand.

Margaret A Brimble (MA)

School of Chemical Sciences, University of Auckland, 23 Symonds Street, Auckland 1142, New Zealand.
Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland 1142, New Zealand.

Patrick Cahill (P)

Cawthron Institute, 98 Halifax Street, Nelson 7010, New Zealand.

Johan Svenson (J)

Cawthron Institute, 98 Halifax Street, Nelson 7010, New Zealand.

Classifications MeSH