Discovery of Phospholipase D Inhibitors with Improved Drug-like Properties and Central Nervous System Penetrance.
Journal
ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073
Informations de publication
Date de publication:
14 Apr 2022
14 Apr 2022
Historique:
received:
18
12
2021
accepted:
01
03
2022
entrez:
22
4
2022
pubmed:
23
4
2022
medline:
23
4
2022
Statut:
epublish
Résumé
Phospholipase D (PLD) is a phospholipase enzyme responsible for hydrolyzing phosphatidylcholine into the lipid signaling molecule, phosphatidic acid, and choline. From a therapeutic perspective, PLD has been implicated in human cancer progression as well as a target for neurodegenerative diseases, including Alzheimer's. Moreover, knockdown of PLD rescues the ALS phenotype in multiple
Identifiants
pubmed: 35450377
doi: 10.1021/acsmedchemlett.1c00682
pmc: PMC9014516
doi:
Types de publication
Journal Article
Langues
eng
Pagination
665-673Informations de copyright
© 2022 American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
Références
Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3670-3673
pubmed: 30528979
J Biol Chem. 1996 Apr 5;271(14):8472-80
pubmed: 8626548
Genetics. 2020 Jul;215(3):747-766
pubmed: 32345615
Nat Rev Drug Discov. 2017 May;16(5):351-367
pubmed: 28209987
Chem Rev. 2011 Oct 12;111(10):6064-119
pubmed: 21936578
J Med Chem. 2009 Nov 12;52(21):6752-6
pubmed: 19827778
Neuropsychobiology. 1984;12(4):211-6
pubmed: 6398861
MMWR Morb Mortal Wkly Rep. 2018 Feb 23;67(7):216-218
pubmed: 29470458
Bioorg Med Chem Lett. 2009 Apr 15;19(8):2240-3
pubmed: 19299128
J Biol Chem. 2013 Jul 12;288(28):20477-87
pubmed: 23723068
ACS Chem Neurosci. 2012 Jan 18;3(1):50-68
pubmed: 22267984
Nutr Metab (Lond). 2017 Feb 6;14:12
pubmed: 28184235
Nat Chem Biol. 2009 Feb;5(2):108-17
pubmed: 19136975
Bioorg Med Chem Lett. 2007 Apr 15;17(8):2310-1
pubmed: 17317170
Nat Chem Biol. 2020 Apr;16(4):391-399
pubmed: 32042197
J Neurosci. 2010 Dec 8;30(49):16419-28
pubmed: 21147981
J Biol Chem. 2000 Aug 4;275(31):23911-8
pubmed: 10801816
Structure. 2000 Jun 15;8(6):655-67
pubmed: 10873862
Science. 2001 Nov 30;294(5548):1942-5
pubmed: 11729323
Front Cell Neurosci. 2019 Jan 23;13:2
pubmed: 30728767
Lancet. 2017 Nov 4;390(10107):2084-2098
pubmed: 28552366
Trends Genet. 2018 Jun;34(6):404-423
pubmed: 29605155
Hum Mol Genet. 2010 Jan 15;19(2):313-28
pubmed: 19864493
J Med Chem. 2013 Mar 28;56(6):2695-9
pubmed: 23445448
Methods Enzymol. 2007;434:49-87
pubmed: 17954242
Bioorg Med Chem Lett. 2009 Apr 1;19(7):1916-20
pubmed: 19268584
Methods Enzymol. 2017;583:309-325
pubmed: 28063496
Neuron. 2014 Jan 22;81(2):333-48
pubmed: 24462097
Anal Biochem. 1997 Oct 1;252(1):1-9
pubmed: 9324933