Chitosan-coated nanostructured lipid carriers for transdermal delivery of tetrahydrocurcumin for breast cancer therapy.

Female Humans Breast Neoplasms / drug therapy Chitosan / chemistry Curcumin / analogs & derivatives Drug Carriers / chemistry Lipids / chemistry Nanostructures / chemistry Particle Size
Breast cancer Chitosan Cytotoxicity Nanostructured lipid carriers Tetrahydrocurcumin Transdermal delivery

Journal

Carbohydrate polymers
ISSN: 1879-1344
Titre abrégé: Carbohydr Polym
Pays: England
ID NLM: 8307156

Informations de publication

Date de publication:
15 Jul 2022
Historique:
received: 01 12 2021
revised: 28 02 2022
accepted: 20 03 2022
entrez: 22 4 2022
pubmed: 23 4 2022
medline: 26 4 2022
Statut: ppublish

Résumé

Chitosan (Ch)-coated nanostructured lipid carriers (NLCs) have great potential for transdermal delivery with high localization of chemotherapeutics in breast cancer. This study used tetrahydrocurcumin (THC), a primary metabolite of curcumin with enhanced antioxidant and anticancer properties, as a model compound to prepare NLCs. Response surface methodology was employed to optimize THC-loaded Ch-coated NLCs (THC-Ch-NLCs) fabricated by high-shear homogenization. The optimized THC-Ch-NLCs had particle size of 244 ± 18 nm, zeta potential of -17.5 ± 0.5 mV, entrapment efficiency of 76.6 ± 0.2% and drug loading of 0.28 ± 0.01%. In vitro release study of THC-Ch-NLCs showed sustained release following the Korsmeyer-Peppas model with Fickian and non-Fickian diffusion at pH 7.4 and 5.5, respectively. THC-Ch-NLCs demonstrated significantly enhanced in vitro skin permeation, cell uptake, and remarkable cytotoxicity toward MD-MBA-231 breast cancer cells compared to the unencapsulated THC, suggesting Ch-NLCs as potential transdermal nanocarriers of THC for triple-negative breast cancer treatment.

Identifiants

DOI: 10.1016/j.carbpol.2022.119401 PMID: 35450653
pubmed: 35450653
pii: S0144-8617(22)00305-8
doi: 10.1016/j.carbpol.2022.119401
pii:
doi:

Substances chimiques

Chitosan 9012-76-4
Curcumin IT942ZTH98
Drug Carriers 0
Lipids 0
tetrahydrocurcumin 00U0645U03

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

119401

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Auteurs

Thien Hoang Truong (TH)

Center of Excellence in Natural Products for Ageing and Chronic Diseases, Chulalongkorn University, Bangkok 10330, Thailand; Pharmaceutical Sciences and Technology Program, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.

Khent Primo Alcantara (KP)

Center of Excellence in Natural Products for Ageing and Chronic Diseases, Chulalongkorn University, Bangkok 10330, Thailand; Pharmaceutical Sciences and Technology Program, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.

Bryan Paul I Bulatao (BPI)

Center of Excellence in Natural Products for Ageing and Chronic Diseases, Chulalongkorn University, Bangkok 10330, Thailand; Pharmaceutical Sciences and Technology Program, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address: bibulatao@up.edu.ph.

Feuangthit Niyamissara Sorasitthiyanukarn (FN)

Center of Excellence in Natural Products for Ageing and Chronic Diseases, Chulalongkorn University, Bangkok 10330, Thailand; Metallurgy and Materials Science Research Institute, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address: Feuangthit.n@chula.ac.th.

Chawanphat Muangnoi (C)

Institute of Nutrition, Mahidol University, Nakhon Pathom 73170, Thailand.

Nonthaneth Nalinratana (N)

Center of Excellence in Natural Products for Ageing and Chronic Diseases, Chulalongkorn University, Bangkok 10330, Thailand; Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address: nonthaneth.n@chula.ac.th.

Opa Vajragupta (O)

Center of Excellence in Natural Products for Ageing and Chronic Diseases, Chulalongkorn University, Bangkok 10330, Thailand; Molecular Probes for Imaging Research Network, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address: opa.v@chula.ac.th.

Pornchai Rojsitthisak (P)

Center of Excellence in Natural Products for Ageing and Chronic Diseases, Chulalongkorn University, Bangkok 10330, Thailand; Department of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address: pornchai.r@chula.ac.th.

Pranee Rojsitthisak (P)

Center of Excellence in Natural Products for Ageing and Chronic Diseases, Chulalongkorn University, Bangkok 10330, Thailand; Metallurgy and Materials Science Research Institute, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address: pranee.l@chula.ac.th.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Chitosan-coated nanostructured lipid carriers...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Chitosan-coated nanostructured lipid carriers...
questionsmedicales.fr › Glucides › Polyosides › Chitine › Chitosane › Chitosan-coated nanostructured lipid carriers...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Diarylheptanoïdes › Curcumine › Chitosan-coated nanostructured lipid carriers...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Vecteurs de médicaments › Chitosan-coated nanostructured lipid carriers...
questionsmedicales.fr › Lipides › Chitosan-coated nanostructured lipid carriers...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Chitosan-coated nanostructured lipid carriers...
questionsmedicales.fr › Phénomènes chimiques › Taille de particule › Chitosan-coated nanostructured lipid carriers...