Accelerated Epigenetic Aging Mediates the Association between Vitamin D Levels and Knee Pain in Community-Dwelling Individuals.
Vitamin D
epigenetic aging
pain
Journal
The journal of nutrition, health & aging
ISSN: 1760-4788
Titre abrégé: J Nutr Health Aging
Pays: France
ID NLM: 100893366
Informations de publication
Date de publication:
2022
2022
Historique:
entrez:
22
4
2022
pubmed:
23
4
2022
medline:
26
4
2022
Statut:
ppublish
Résumé
To examine the relationship between Vitamin D status and pain intensity and disability in individuals with and without knee pain, and to examine the role of epigenetics in this relationship. Cross-sectional analysis of data from the UPLOAD-2 study (Understanding Pain and Limitations in OsteoArthritic Disease-2). 189 individuals aged 45-65 years and older. Serum Vitamin D levels, pain related interference and characteristic pain intensity measures, and the epigenetic clock GrimAge derived from blood analyses. Lower Vitamin D was associated with advanced epigenetic aging (AgeAccelGrim), greater pain and disability and that (AgeAccelGrim) mediated the relationship between Vitamin D status and self-reported pain (ab = -0.0799; CI [-0.1492, -0.0237]) and disability (ab = -0.0669; CI [-0.1365, -0.0149]) outcomes. These data support the notion that lifestyle factors such as nutrition status play a key role in aging process, as well as the development and maintenance of age-related diseases such as pain. Modifying nutrition status could help promote healthy aging and reduce pain.
Identifiants
pubmed: 35450986
doi: 10.1007/s12603-022-1758-z
pmc: PMC10161927
mid: NIHMS1865868
doi:
Substances chimiques
Vitamins
0
Vitamin D
1406-16-2
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
318-323Subventions
Organisme : NIA NIH HHS
ID : R01 AG059809
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG067757
Pays : United States
Organisme : NIA NIH HHS
ID : R37 AG033906
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR003096
Pays : United States
Déclaration de conflit d'intérêts
The authors have no conflicts of interest to declare.
Références
Neurosci Bull. 2021 Sep;37(9):1289-1302
pubmed: 34076854
Genes Immun. 2016 Jun;17(4):213-9
pubmed: 26986782
Mol Pain. 2019 Jan-Dec;15:1744806919871819
pubmed: 31394966
Mediterr J Rheumatol. 2017 Dec 22;28(4):206-209
pubmed: 32185284
Pain Manag. 2022 Mar;12(2):168-179
pubmed: 34431328
Pain Ther. 2020 Dec;9(2):487-498
pubmed: 33085012
Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):E1678-E1687
pubmed: 28196884
Int J Mol Sci. 2017 Oct 18;18(10):
pubmed: 29057787
Aging (Albany NY). 2016 Sep 28;8(9):2222-2231
pubmed: 27689435
Pain Med. 2020 Jan 1;21(1):150-160
pubmed: 30865775
Nat Rev Genet. 2012 May 29;13(7):484-92
pubmed: 22641018
Mol Cell Endocrinol. 2017 Sep 15;453:36-45
pubmed: 28400273
Sci Rep. 2018 Jan 22;8(1):1364
pubmed: 29358690
Mol Nutr Food Res. 2020 Oct 20;:e2000437
pubmed: 33079481
J Pain. 2019 Feb;20(2):146-160
pubmed: 30096445
Clin J Pain. 2018 Feb;34(2):182-189
pubmed: 28542024
Pain. 1992 Aug;50(2):133-149
pubmed: 1408309
Pain. 2000 Dec 1;88(3):303-308
pubmed: 11068118
Clin Epigenetics. 2018 Jun 20;10:84
pubmed: 29977410
J Nutr. 2006 Apr;136(4):1126-9
pubmed: 16549493
PLoS One. 2019 Jul 17;14(7):e0219064
pubmed: 31315131
Front Physiol. 2014 Apr 29;5:164
pubmed: 24808866
EClinicalMedicine. 2020 Nov 26;29-30:100587
pubmed: 34505846
Phys Med Rehabil Clin N Am. 2015 May;26(2):309-20
pubmed: 25952067
Rheum Dis Clin North Am. 2012 Feb;38(1):13-27
pubmed: 22525840
J Renin Angiotensin Aldosterone Syst. 2011 Jun;12(2):125-8
pubmed: 21628362
Genome Biol. 2011;12(1):R10
pubmed: 21251332
Scand J Pain. 2017 Oct;17:316-324
pubmed: 28927908
J Neuroimmunol. 2018 Nov 15;324:100-114
pubmed: 30267995
Neuropsychopharmacology. 2013 Jan;38(1):23-38
pubmed: 22781841
Aging Dis. 2017 May 2;8(3):346-353
pubmed: 28580189
Pain Res Manag. 2016;2016:7657329
pubmed: 27445627
Pain. 2019 Jan;160(1):88-94
pubmed: 30586076
Neurobiol Pain. 2021 Jun 15;10:100066
pubmed: 34195483
J Gerontol A Biol Sci Med Sci. 2020 Oct 15;75(11):2056-2063
pubmed: 32324874
Aging (Albany NY). 2019 Jan 21;11(2):303-327
pubmed: 30669119
Orthop J Sports Med. 2017 Jun 20;5(6):2325967117711376
pubmed: 28680892
J Womens Health (Larchmt). 2016 Jul;25(7):752-60
pubmed: 27028709
J Transl Med. 2019 Mar 18;17(1):87
pubmed: 30885216
Nutrients. 2017 Jun 14;9(6):
pubmed: 28613268
Crit Rev Food Sci Nutr. 2017 Jul 24;57(11):2404-2411
pubmed: 26565606