Astrogenesis in the murine dentate gyrus is a life-long and dynamic process.
adult neurogenesis
astrocytes
astrogenesis
neural stem cells
voluntary exercise
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
01 06 2022
01 06 2022
Historique:
revised:
25
03
2022
received:
10
12
2021
accepted:
30
03
2022
pubmed:
23
4
2022
medline:
3
6
2022
entrez:
22
4
2022
Statut:
ppublish
Résumé
Astrocytes are highly abundant in the mammalian brain, and their functions are of vital importance for all aspects of development, adaption, and aging of the central nervous system (CNS). Mounting evidence indicates the important contributions of astrocytes to a wide range of neuropathies. Still, our understanding of astrocyte development significantly lags behind that of other CNS cells. We here combine immunohistochemical approaches with genetic fate-mapping, behavioural paradigms, single-cell transcriptomics, and in vivo two-photon imaging, to comprehensively assess the generation and the proliferation of astrocytes in the dentate gyrus (DG) across the life span of a mouse. Astrogenesis in the DG is initiated by radial glia-like neural stem cells giving rise to locally dividing astrocytes that enlarge the astrocyte compartment in an outside-in-pattern. Also in the adult DG, the vast majority of astrogenesis is mediated through the proliferation of local astrocytes. Interestingly, locally dividing astrocytes were able to adapt their proliferation to environmental and behavioral stimuli revealing an unexpected plasticity. Our study establishes astrocytes as enduring plastic elements in DG circuits, implicating a vital contribution of astrocyte dynamics to hippocampal plasticity.
Identifiants
pubmed: 35451150
doi: 10.15252/embj.2021110409
pmc: PMC9156974
doi:
Banques de données
GEO
['GSE190399']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e110409Informations de copyright
© 2022 The Authors. Published under the terms of the CC BY NC ND 4.0 license.
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