Cannabis use and the risk of periodontitis: A two-sample Mendelian randomization study.
Mendelian randomization
cannabis
confounding
periodontitis
risk factors
Journal
Journal of clinical periodontology
ISSN: 1600-051X
Titre abrégé: J Clin Periodontol
Pays: United States
ID NLM: 0425123
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
revised:
18
03
2022
received:
22
11
2021
accepted:
15
04
2022
pubmed:
23
4
2022
medline:
22
6
2022
entrez:
22
4
2022
Statut:
ppublish
Résumé
This study aimed to leverage human genetic data to investigate whether cannabis use causally affects periodontitis. Data were obtained from summary statistics of genome-wide association studies of lifetime cannabis use (N = 184,765), cannabis use disorder (17,068 cases; 357,219 controls), and periodontitis (17,353 cases; 28,210 controls). We performed two-sample Mendelian randomization (MR) analysis using 6 genetic variants as instrumental variables for lifetime cannabis use and 11 variants as instruments for cannabis use disorder to estimate associations with periodontitis. There was no evidence for an association between genetic liability for lifetime cannabis use or cannabis use disorder with periodontitis. The estimates from the primary analyses were supported in multivariable MR analysis, which considered potential pleiotropic pathways and in weak instrument analyses. This study provides little evidence to support a detrimental effect of genetic liability for cannabis use on periodontal health.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
654-661Informations de copyright
© 2022 The Authors. Journal of Clinical Periodontology published by John Wiley & Sons Ltd.
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