Trends in the inpatient burden of alcohol-related liver disease among women hospitalized in the United States.
National Inpatient Sample
alcohol-related hepatitis
alcohol-related liver disease
hospitalized women
Journal
Liver international : official journal of the International Association for the Study of the Liver
ISSN: 1478-3231
Titre abrégé: Liver Int
Pays: United States
ID NLM: 101160857
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
revised:
23
03
2022
received:
06
12
2021
accepted:
08
04
2022
pubmed:
23
4
2022
medline:
25
6
2022
entrez:
22
4
2022
Statut:
ppublish
Résumé
Alcohol-related liver disease (ALD) is the leading indication for liver transplantation in the United States, but disparities for women with ALD exist. We sought to characterize trends in ALD hospitalizations and mortality among women. Using the National Inpatient Sample, we evaluated ALD and non-ALD discharges from 2003 to 2017. Multivariable logistic regression was used to evaluate mortality. ALD increased more rapidly among women, with alcohol hepatitis (AH) rising the most. When stratified by age and sex, changes in alcohol-related cirrhosis (AC) and AH were greater in women in nearly all age groups. Similar increases were present when stratified by race, notably for Native American and Asian women. AH mortality increased in women in almost all age groups. While ALD remains predominantly male, discharges and mortality have disproportionately increased among women, particularly in young women and Native Americans. These findings shed light on populations in need of intensive public health interventions.
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1557-1561Subventions
Organisme : NIAAA NIH HHS
ID : K23 AA026333
Pays : United States
Informations de copyright
© 2022 John Wiley & Sons A/S . Published by John Wiley & Sons Ltd.
Références
Lee BP, Vittinghoff E, Dodge JL, Cullaro G, Terrault NA. National Trends and long-term outcomes of liver transplant for alcohol-associated liver disease in the United States. JAMA Intern Med. 2019;179:340-348.
Guy J, Peters MG. Liver disease in women: the influence of gender on epidemiology, natural history, and patient outcomes. Gastroenterol Hepatol (N Y). 2013;9:633-639.
Szabo G. Women and alcoholic liver disease - warning of a silent danger. Nat Rev Gastroenterol Hepatol. 2018;15:253-254.
Grant BF, Chou SP, Saha TD, et al. Prevalence of 12-month alcohol use, high-risk drinking, and DSM-IV alcohol use disorder in the United States, 2001−2002 to 2012-2013: results from the National Epidemiologic Survey on alcohol and related conditions. JAMA Psychiat. 2017;74:911-923.
Tapper EB, Parikh ND. Mortality due to cirrhosis and liver cancer in the United States, 1999-2016: observational study. BMJ. 2018;362:k2817.
Mellinger JL, Shedden K, Winder GS, et al. The high burden of alcoholic cirrhosis in privately insured persons in the United States. Hepatology. 2018;68:872-882.
Julien J, Ayer T, Bethea ED, Tapper EB, Chhatwal J. Projected prevalence and mortality associated with alcohol-related liver disease in the USA, 2019-40: a modelling study. Lancet Public Health. 2020;5:e316-e323.
Yoon YH, Chen CM, Slater ME, Jung MK, White AM. Trends in premature deaths from alcoholic liver disease in the U.S., 1999-2018. Am J Prev Med. 2020;59:469-480.
Jones CM, Clayton HB, Deputy NP, et al. Prescription opioid misuse and use of alcohol and other substances among high school students - youth risk behavior survey, United States, 2019. MMWR Suppl. 2020;69:38-46.
McCance-Katz EF. The Substance Abuse and Mental Health Services Administration (SAMHSA): new directions. Psychiatr Serv. 2018;69:1046-1048.
Sancar F, Abbasi J, Bucher K. Mortality among American Indians and Alaska natives. JAMA. 2018;319:112.
Moon AM, Yang JY, Barritt AS 4th, et al. Rising mortality from alcohol-associated liver disease in the United States in the 21st century. Am J Gastroenterol 2020;115:79-87.