Aryl Hydrocarbon Receptor-Dependent and -Independent Pathways Mediate Curcumin Anti-Aging Effects.
Caenorhabditis elegans
aryl hydrocarbon receptor
curcumin
endothelial cells
in silico
in vitro
in vivo
mice
oxidative stress
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
23 Mar 2022
23 Mar 2022
Historique:
received:
03
03
2022
revised:
18
03
2022
accepted:
19
03
2022
entrez:
23
4
2022
pubmed:
24
4
2022
medline:
24
4
2022
Statut:
epublish
Résumé
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor whose activity can be modulated by polyphenols, such as curcumin. AhR and curcumin have evolutionarily conserved effects on aging. Here, we investigated whether and how the AhR mediates the anti-aging effects of curcumin across species. Using a combination of in vivo, in vitro, and in silico analyses, we demonstrated that curcumin has AhR-dependent or -independent effects in a context-specific manner. We found that in
Identifiants
pubmed: 35453298
pii: antiox11040613
doi: 10.3390/antiox11040613
pmc: PMC9024831
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : IRTG1902-P1
Organisme : Jürgen Manchot Stiftung
ID : PhD scholarship
Organisme : Deutsche Forschungsgemeinschaft
ID : IRTG1902-P2
Organisme : Deutsche Forschungsgemeinschaft
ID : VE366/6-1
Organisme : Deutsche Forschungsgemeinschaft
ID : VE366/8-1
Références
Worm. 2016 Aug 31;5(4):e1230585
pubmed: 28090393
PLoS One. 2013 Jul 26;8(7):e69956
pubmed: 23922869
Biol Chem. 2010 Nov;391(11):1235-48
pubmed: 20868221
Cells. 2021 Dec 29;11(1):
pubmed: 35011662
J Nutr Metab. 2016;2016:1089653
pubmed: 27630772
Biomed Res Int. 2018 Jun 10;2018:6058784
pubmed: 29984241
Chem Biol Interact. 2002 Sep 20;141(1-2):131-60
pubmed: 12213389
Mech Ageing Dev. 2009 Jul;130(7):461-5
pubmed: 19442682
Nature. 1998 Oct 29;395(6705):854
pubmed: 9804418
Eur J Nutr. 2016 Mar;55(2):741-747
pubmed: 25851110
Nat Cell Biol. 2002 Oct;4(10):743-9
pubmed: 12244325
J Biol Chem. 2000 Nov 17;275(46):36407-14
pubmed: 10961990
Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10417-22
pubmed: 12122205
Nature. 2014 Apr 17;508(7496):406-10
pubmed: 24695221
J Dermatol Sci. 2019 Oct;96(1):33-41
pubmed: 31543430
Toxicol Appl Pharmacol. 1999 Aug 15;159(1):41-51
pubmed: 10448124
J Tradit Complement Med. 2020 Apr 01;10(5):434-439
pubmed: 32953558
Chem Biol Interact. 2002 Sep 20;141(1-2):3-24
pubmed: 12213382
J Comp Physiol B. 2005 May;175(4):221-30
pubmed: 15900503
Bioinformatics. 2009 Apr 15;25(8):1091-3
pubmed: 19237447
Drug Discov Today. 2013 May;18(9-10):479-86
pubmed: 23220635
J Biol Chem. 1998 Oct 9;273(41):26969-76
pubmed: 9756946
PLoS Biol. 2018 Jun 21;16(6):e2004408
pubmed: 29927970
Arterioscler Thromb Vasc Biol. 2008 Nov;28(11):1967-74
pubmed: 18757291
Arch Biochem Biophys. 2007 Oct 15;466(2):267-73
pubmed: 17880909
Curr Mol Med. 2020;20(2):116-133
pubmed: 31622191
Invest Ophthalmol Vis Sci. 2010 Apr;51(4):2109-17
pubmed: 20007828
Neuron. 2013 Jul 24;79(2):266-80
pubmed: 23889932
Methods. 2003 Aug;30(4):313-21
pubmed: 12828945
Circ Res. 2012 Apr 27;110(9):1252-64
pubmed: 22539758
Annu Rev Biophys Biomol Struct. 2000;29:291-325
pubmed: 10940251
Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6731-6
pubmed: 8692887
Bioinformatics. 2009 Jun 1;25(11):1463-5
pubmed: 19346324
J Mol Biol. 1993 Dec 5;234(3):779-815
pubmed: 8254673
Methods Enzymol. 1990;186:343-55
pubmed: 2172711
Biochemistry. 2013 Jan 29;52(4):714-25
pubmed: 23286227
Cancer Res. 2002 Oct 1;62(19):5451-6
pubmed: 12359752
J Biol Chem. 2003 Jun 20;278(25):22432-6
pubmed: 12730222
Science. 1995 May 5;268(5211):722-6
pubmed: 7732381
J Biol Chem. 1976 Aug 25;251(16):4936-46
pubmed: 956169
Dev Biol. 2006 Oct 15;298(2):606-15
pubmed: 16919260
Int J Biol Macromol. 2017 Jul;100:89-96
pubmed: 27327907
Protein Sci. 2006 Nov;15(11):2507-24
pubmed: 17075131
Exp Gerontol. 2013 Feb;48(2):269-76
pubmed: 23142245
Structure. 2002 Feb;10(2):175-84
pubmed: 11839303
J Toxicol Sci. 2008 Oct;33(4):405-13
pubmed: 18827440
Circ Res. 1986 Oct;59(4):390-7
pubmed: 2431805
Molecules. 2017 Mar 09;22(3):
pubmed: 28282941
Mech Ageing Dev. 2011 Oct;132(10):480-7
pubmed: 21855561
Aging (Albany NY). 2020 Dec 13;13(1):104-133
pubmed: 33349622
Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3604-3613
pubmed: 30733286
Proc Natl Acad Sci U S A. 2007 May 22;104(21):8851-6
pubmed: 17502624
Nucleic Acids Res. 2015 Apr 20;43(7):e47
pubmed: 25605792
J Biochem Mol Toxicol. 2021 Mar;35(3):e22658
pubmed: 33118292
Comp Biochem Physiol C Toxicol Pharmacol. 2010 Apr;151(3):318-24
pubmed: 20045492
Chem Res Toxicol. 2016 Jan 19;29(1):75-86
pubmed: 26686552
Curr Drug Metab. 2011 Feb;12(2):89-103
pubmed: 21401513
Development. 2004 Feb;131(4):819-28
pubmed: 14757639
Nat Methods. 2012 Jun 28;9(7):676-82
pubmed: 22743772
Bioinformatics. 2009 Feb 1;25(3):415-6
pubmed: 19106121
PLoS Genet. 2008 Mar 21;4(3):e1000027
pubmed: 18369446
Arh Hig Rada Toksikol. 2010 Dec;61(4):445-53
pubmed: 21183436
Dose Response. 2014 Jan 31;12(2):288-341
pubmed: 24910588
Bioinformatics. 2010 Oct 1;26(19):2363-7
pubmed: 20688976
PLoS One. 2011;6(8):e23525
pubmed: 21858155
J Biol Chem. 1994 Nov 4;269(44):27337-43
pubmed: 7961644
Microvasc Res. 2021 Sep;137:104179
pubmed: 34051271
Food Funct. 2017 Apr 19;8(4):1414-1437
pubmed: 28287659
Cancer Sci. 2008 Dec;99(12):2518-24
pubmed: 19018768
PLoS Genet. 2014 Sep 25;10(9):e1004673
pubmed: 25255223
Genome Res. 2003 Nov;13(11):2498-504
pubmed: 14597658
Biomed Res Int. 2014;2014:520763
pubmed: 24527450
Aquat Toxicol. 2015 Oct;167:200-8
pubmed: 26349946
Chemosphere. 2015 Nov;139:496-503
pubmed: 26291679
Sci Rep. 2015 Jan 26;5:8022
pubmed: 25620626
PLoS One. 2012;7(2):e31424
pubmed: 22348084
Oncotarget. 2016 Aug 30;7(35):56147-56152
pubmed: 27528229
Sex Dev. 2008;2(1):1-11
pubmed: 18418030
Int J Biochem Cell Biol. 2009 Jan;41(1):40-59
pubmed: 18662800
Biochem Pharmacol. 2007 Jun 15;73(12):1853-62
pubmed: 17266942
Nucleic Acids Res. 2001 May 1;29(9):e45
pubmed: 11328886
Mol Cell Biol. 2004 Jun;24(12):5209-22
pubmed: 15169886
Cancer Res. 1984 Apr;44(4):1426-32
pubmed: 6322977
Nat Commun. 2019 Jul 25;10(1):3323
pubmed: 31346165
Front Physiol. 2020 Jan 14;10:1561
pubmed: 32009975
Nature. 2019 Dec;576(7786):301-305
pubmed: 31801997
Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W116-8
pubmed: 16844972
Dev Biol. 2004 Jun 1;270(1):64-75
pubmed: 15136141
Gene. 2001 Oct 31;278(1-2):223-34
pubmed: 11707340
Nature. 2004 Aug 5;430(7000):686-9
pubmed: 15254550
J Agric Food Chem. 2003 Aug 27;51(18):5478-87
pubmed: 12926901
Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):2844-9
pubmed: 9501178
Methods. 2001 Dec;25(4):402-8
pubmed: 11846609
J Nutr Sci Vitaminol (Tokyo). 2005 Oct;51(5):369-73
pubmed: 16392709
Biochem J. 2008 Jan 1;409(1):205-13
pubmed: 17714076
Biochem Pharmacol. 1998 Jul 15;56(2):197-206
pubmed: 9698073
Protein Sci. 2000 Sep;9(9):1753-73
pubmed: 11045621
Nat Methods. 2015 Feb;12(2):115-21
pubmed: 25633503
Chem Biol Interact. 2016 May 25;252:19-27
pubmed: 27041069
Nature. 2011 Apr 14;472(7342):226-9
pubmed: 21451522
Cell Metab. 2019 May 7;29(5):1182-1191.e4
pubmed: 30799287
Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13743-8
pubmed: 9391097
Environ Health Perspect. 2003 Dec;111(16):1877-82
pubmed: 14644660
J Biol Chem. 2010 Dec 10;285(50):38801-10
pubmed: 20876576
J Neurosci. 2001 Nov 1;21(21):8370-7
pubmed: 11606625
Cell Mol Life Sci. 2016 Sep;73(17):3221-47
pubmed: 27100828
Arch Biochem Biophys. 2014 Oct 1;559:75-90
pubmed: 24875147
Vet Pathol. 1997 Nov;34(6):605-14
pubmed: 9396142
Sci Rep. 2016 Jan 21;6:19618
pubmed: 26790370
Genetics. 2010 Nov;186(3):857-66
pubmed: 20805557
Immunity. 2018 Jan 16;48(1):19-33
pubmed: 29343438
FEBS Lett. 2000 Jul 7;476(3):213-7
pubmed: 10913616
J Chem Inf Model. 2011 Nov 28;51(11):2868-81
pubmed: 21981577