Melatonin Regulates Lipid Metabolism in Porcine Cumulus-Oocyte Complexes via the Melatonin Receptor 2.
cumulus–oocyte complexes
cytoplasmic maturation
lipid metabolism
melatonin receptor
reactive oxygen species
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
31 Mar 2022
31 Mar 2022
Historique:
received:
28
01
2022
revised:
29
03
2022
accepted:
29
03
2022
entrez:
23
4
2022
pubmed:
24
4
2022
medline:
24
4
2022
Statut:
epublish
Résumé
Previous studies suggest that the inclusion of melatonin (MTn) in in vitro maturation protocols improves the developmental competence of oocytes by scavenging reactive oxygen species (ROS). However, the molecular mechanisms integrating melatonin receptor (MT)-mediated lipid metabolism and redox signaling during in vitro cumulus-oocyte complex (COC) development still remain unclear. Here, we aimed to elucidate the potential role of MTn receptors in lipid metabolic adjustments during in vitro porcine COC development. We observed that MTn-mediated G
Identifiants
pubmed: 35453372
pii: antiox11040687
doi: 10.3390/antiox11040687
pmc: PMC9027243
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : National Natural Science Foundation of China
ID : 32002179
Organisme : National Natural Science Foundation of China
ID : 31872360
Organisme : National Key Research and Development Program of China
ID : 2021YFA0805902
Organisme : Excellent Youth Project of Heilongjiang Province Natural Science Foundation of China
ID : YQ2020C007
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